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Literature summary for 2.7.11.10 extracted from

  • Cummins, E.P.; Berra, E.; Comerford, K.M.; Ginouves, A.; Fitzgerald, K.T.; Seeballuck, F.; Godson, C.; Nielsen, J.E.; Moynagh, P.; Pouyssegur, J.; Taylor, C.T.
    Prolyl hydroxylase-1 negatively regulates IkappaB kinase-beta, giving insight into hypoxia-induced NFkappaB activity (2006), Proc. Natl. Acad. Sci. USA, 103, 18154-18159.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.10

Activating Compound

Activating Compound Comment Organism Structure
additional information hypoxia activates NFkappaB through a pathway involving activation of IkappaB kinase-beta, IKKbeta Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
transient expression of wild-type and mutant IKKbeta in HeLa cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
P191A inactive IKKbeta mutant Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information prolyl hydroxylase-1 negatively regulates IKKbeta, hydroxylation represses IKKbeta activity by altering protein expression or by preventing its activation through phosphorylation on S177/S181 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Homo sapiens 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + IkappaBalpha Homo sapiens a step in NF-kappaB activation, the IKK complex, composed of IKKalpha, IKKbeta, and NEMO/IKKgamma, is the convergence point for many diverse NFkappaB-activating stimuli including TNFalpha, LPS, and IL-1, overview, IKKbeta is the primary positive regulator of NFkappaB activity in inflammatory processes, is the molecular link between inflammation and cancer ADP + phosphorylated IkappaBalpha
-
 ?
additional information Homo sapiens hypoxia alters the cellular pool of IKKalpha and IKKbeta, and activates NFkappaB through a pathway involving activation of IkappaB kinase-beta, IKKbeta, leading to phosphorylation-dependent degradation of IkappaBalpha and liberation of NFkappaB, overview, hypoxia-induced activation of the NFkappaB pathway is independent of HIF-1alpha, prolyl hydroxylase-1 negatively regulates IKKbeta ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
additional information within its activation loop, IKKbeta contains an evolutionarily conserved LxxLAP consensus motif for hydroxylation by prolyl hydroxylases Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + IkappaBalpha
-
 Homo sapiens ADP + phosphorylated IkappaBalpha
-
 ?
ATP + IkappaBalpha a step in NF-kappaB activation, the IKK complex, composed of IKKalpha, IKKbeta, and NEMO/IKKgamma, is the convergence point for many diverse NFkappaB-activating stimuli including TNFalpha, LPS, and IL-1, overview, IKKbeta is the primary positive regulator of NFkappaB activity in inflammatory processes, is the molecular link between inflammation and cancer Homo sapiens ADP + phosphorylated IkappaBalpha
-
 ?
additional information hypoxia alters the cellular pool of IKKalpha and IKKbeta, and activates NFkappaB through a pathway involving activation of IkappaB kinase-beta, IKKbeta, leading to phosphorylation-dependent degradation of IkappaBalpha and liberation of NFkappaB, overview, hypoxia-induced activation of the NFkappaB pathway is independent of HIF-1alpha, prolyl hydroxylase-1 negatively regulates IKKbeta Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
More within its activation loop, IKKbeta and IKKalpha contain an evolutionarily conserved LxxLAP consensus motif for hydroxylation by prolyl hydroxylases, while p65, p50, IkappaBalpha, and NEMO/IKKgamma are without this sequence Homo sapiens

Synonyms

Synonyms Comment Organism
IkappaB kinase-beta
-
 Homo sapiens
IKKbeta
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens