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Literature summary for 2.7.11.10 extracted from

  • Wegener, E.; Oeckinghaus, A.; Papadopoulou, N.; Lavitas, L.; Schmidt-Supprian, M.; Ferch, U.; Mak, T.W.; Ruland, J.; Heissmeyer, V.; Krappmann, D.
    Essential role for IkappaB kinase beta in remodeling Carma1-Bcl10-Malt1 complexes upon T cell activation (2006), Mol. Cell, 23, 13-23.
    View publication on PubMed
Search for more literature for 2.7.11.10

Protein Variants

Protein Variants Comment Organism
additional information IKK knockout mice show downregulation of the CBM complex components Carma1 and Malt1, and impaired degradation of IkappaBalpha, overview Mus musculus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Mus musculus
Mg2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + Bcl Mus musculus phosphorylation at the C-terminus of Bcl by IKKbeta disrupts Bcl10/Malt1 association and Bcl10-mediated signaling ADP + phosphorylated Bcl
-
 ?
ATP + Bcl Homo sapiens phosphorylation at the C-terminus of Bcl by IKKbeta disrupts Bcl10/Malt1 association and Bcl10-mediated signaling ADP + phosphorylated Bcl
-
 ?
additional information Mus musculus IkappaB kinase beta plays an essential role in remodeling Carma1-Bcl10-Malt1 complexes upon T cell activation, T cell receptor signaling to IkappaB kinase/NF-kappaB is controlled by PKCtheta-dependent activation of the Carma1, Bcl10, and Malt1 CBM complex, IKKbeta triggers the CBM complex formation and phosphorylation of Bcl by PMA/ionomycin or CD3/CD28, regulation, overview ?
-
 ?
additional information Homo sapiens IkappaB kinase beta plays an essential role in remodeling Carma1-Bcl10-Malt1 complexes upon T cell activation, T cell receptor signaling to IkappaB kinase/NF-kappaB is controlled by PKCtheta-dependent activation of the Carma1, Bcl10, and Malt1 CBM complex, IKKbeta triggers the CBM complex formation and phosphorylation of Bcl by PMA/ionomycin or CD3/CD28, regulation, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
JURKAT cell
-
 Homo sapiens
-
lymphocyte primary Homo sapiens
-
peripheral blood mononuclear cell
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + Bcl phosphorylation at the C-terminus of Bcl by IKKbeta disrupts Bcl10/Malt1 association and Bcl10-mediated signaling Mus musculus ADP + phosphorylated Bcl
-
 ?
ATP + Bcl phosphorylation at the C-terminus of Bcl by IKKbeta disrupts Bcl10/Malt1 association and Bcl10-mediated signaling Homo sapiens ADP + phosphorylated Bcl
-
 ?
ATP + Bcl phosphorylation at the C-terminus of Bcl by IKKbeta, inactive with a C-terminal 93 amino acid-deletion mutant of Bcl Mus musculus ADP + phosphorylated Bcl
-
 ?
ATP + Bcl phosphorylation at the C-terminus of Bcl by IKKbeta, inactive with a C-terminal 93 amino acid-deletion mutant of Bcl Homo sapiens ADP + phosphorylated Bcl
-
 ?
additional information IkappaB kinase beta plays an essential role in remodeling Carma1-Bcl10-Malt1 complexes upon T cell activation, T cell receptor signaling to IkappaB kinase/NF-kappaB is controlled by PKCtheta-dependent activation of the Carma1, Bcl10, and Malt1 CBM complex, IKKbeta triggers the CBM complex formation and phosphorylation of Bcl by PMA/ionomycin or CD3/CD28, regulation, overview Mus musculus ?
-
 ?
additional information IkappaB kinase beta plays an essential role in remodeling Carma1-Bcl10-Malt1 complexes upon T cell activation, T cell receptor signaling to IkappaB kinase/NF-kappaB is controlled by PKCtheta-dependent activation of the Carma1, Bcl10, and Malt1 CBM complex, IKKbeta triggers the CBM complex formation and phosphorylation of Bcl by PMA/ionomycin or CD3/CD28, regulation, overview Homo sapiens ?
-
 ?

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Mus musculus
ATP
-
 Homo sapiens