Protein Variants | Comment | Organism |
---|---|---|
additional information | IKK subunit-specific small interfering RNAs and cells deficient in individual IKK subunits show that IKKalpha subunit, not IKKbeta, is required for reovirus-induced NF-kappaB activation and apoptosis, overview, NF-kappaB activation and apoptosis are delayed in cells deficient in the IKK complex components IKKgamma/NEMO, overview | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Homo sapiens | 5737 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Homo sapiens | |
Mn2+ | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | IKK is responsible for activation of NF-kappaB by initiating the degradation of the NF-kappaB inhibitor IkappaB, subunits IKKalpha and IKKgamma/NEMO, not IKKbeta, are required for reovirus-induced NF-kappaB activation and apoptosis, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HeLa cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | IKK is responsible for activation of NF-kappaB by initiating the degradation of the NF-kappaB inhibitor IkappaB, subunits IKKalpha and IKKgamma/NEMO, not IKKbeta, are required for reovirus-induced NF-kappaB activation and apoptosis, overview | Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
oligomer | the IKK complex is built by subunits IKKalpha, IKKbeta, and IKKgamma/NEMO | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
IKK | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |