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Literature summary for 2.7.11.10 extracted from
- Simvastatin potentiates TNF-alpha-induced apoptosis through the down-regulation of NF-kappaB-dependent antiapoptotic gene products: role of IkappaBalpha kinase and TGF-beta-activated kinase-1 (2007), J. Immunol., 178, 2507-2516.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | TNFalpha induces activation of IkappaB kinase, which is inhibited by simvastatin | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | simvastatin inhibits the TNFalpha-induced activation of IkappaB kinase and activation of NF-kappaB in vitro and in vivo, simvastatin highly affects the whole NF-kappaB-dependent pathway of signaling, overview | Homo sapiens |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | - |
Homo sapiens |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + IkappaBalpha | Homo sapiens | - |
ADP + phosphorylated IkappaBalpha | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| KBM-5 cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + IkappaBalpha | - |
Homo sapiens | ADP + phosphorylated IkappaBalpha | - |
? | |
| ATP + IkappaBalpha | recombinant GST-fusion substrate | Homo sapiens | ADP + phosphorylated IkappaBalpha | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| IkappaBalpha kinase | - |
Homo sapiens |
| IKKalpha | - |
Homo sapiens |
| IKKbeta | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 30 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
assay at | Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Homo sapiens | |
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Release 2023.1 (January 2023)
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