Any feedback?
Literature summary for 2.7.11.10 extracted from
- IkB kinases: key regulators of the NF-kB pathway (2004), Trends Biochem. Sci., 29, 72-79.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| NEMO | i.e. NF-kappaB essential modifier, complexing with IkappaB kinase-gamma and ubiquitination, involving the zinc finger of NEMO and c-IAP1, are required for activation of the IkappaB kinase complex by inflammatory stimuli such as tumor necrosis factor TNFalpha | Mus musculus | |
| NEMO | i.e. NF-kappaB essential modifier, complexing with IkappaB kinase-gamma and ubiquitination, involving the zinc finger of NEMO and c-IAP1, are required for activation of the IkappaB kinase complex by inflammatory stimuli such as tumor necrosis factor TNFalpha | Homo sapiens | |
| tumor necrosis factor TNFalpha | cytokines activate the IKK complex, mechanism, overview | Mus musculus | |
| tumor necrosis factor TNFalpha | cytokines activate the IKK complex, mechanism, overview | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | predominantly | Mus musculus | 5737 | - |
| cytoplasm | predominantly | Homo sapiens | 5737 | - |
| nucleus | - |
Mus musculus | 5634 | - |
| nucleus | - |
Homo sapiens | 5634 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + [acetylated histone H3 protein] | Mus musculus | IKKalpha is required for histone function regulation in the nucleus | ADP + [acetylated histone H3 phosphoprotein] | - |
? |  |
| ATP + [acetylated histone H3 protein] | Homo sapiens | IKKalpha is required for histone function regulation in the nucleus | ADP + [acetylated histone H3 phosphoprotein] | - |
? | |
| ATP + [IkappaB protein] | Mus musculus | - |
ADP + [IkappaB phosphoprotein] | - |
? | |
| ATP + [IkappaB protein] | Homo sapiens | - |
ADP + [IkappaB phosphoprotein] | - |
? | |
| additional information | Mus musculus | IKKalpha, not IKKbeta, is required for epidermal regeneration, IkappaB kinases are essential key regulators of the canonical and noncanonical NFkappaB pathways important for the expression of a wide variety of genes that are involved in the control of immune and inflammatory response, and in the regulation of cellular proliferation and survival, mechanism, overview | ? | - |
? | |
| additional information | Homo sapiens | IKKalpha, not IKKbeta, is required for epidermal regeneration, IkappaB kinases are essential key regulators of the canonical and noncanonical NFkappaB pathways important for the expression of a wide variety of genes that are involved in the control of immune and inflammatory response, and in the regulation of cellular proliferation and survival, mechanism, overview | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
IkappaBalpha and IkappaBbeta | - |
| Mus musculus | - |
IkappaBalpha and IkappaBbeta | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| embryo | - |
Mus musculus | - |
| epidermis | - |
Mus musculus | - |
| fibroblast | - |
Homo sapiens | - |
| fibroblast | adult and embryonic | Mus musculus | - |
| HeLa cell | - |
Homo sapiens | - |
| MEF cell | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + [acetylated histone H3 protein] | IKKalpha is required for histone function regulation in the nucleus | Mus musculus | ADP + [acetylated histone H3 phosphoprotein] | - |
? | |
| ATP + [acetylated histone H3 protein] | IKKalpha is required for histone function regulation in the nucleus | Homo sapiens | ADP + [acetylated histone H3 phosphoprotein] | - |
? | |
| ATP + [acetylated histone H3 protein] | phosphorylation at Ser10 | Mus musculus | ADP + [acetylated histone H3 phosphoprotein] | - |
? | |
| ATP + [acetylated histone H3 protein] | phosphorylation at Ser10 | Homo sapiens | ADP + [acetylated histone H3 phosphoprotein] | - |
? | |
| ATP + [IkappaB protein] | - |
Mus musculus | ADP + [IkappaB phosphoprotein] | - |
? | |
| ATP + [IkappaB protein] | - |
Homo sapiens | ADP + [IkappaB phosphoprotein] | - |
? | |
| ATP + [IkappaBalpha protein] | phosphorylation at Ser32 and Ser36 | Mus musculus | ADP + [IkappaBalpha phosphoprotein] | - |
? | |
| ATP + [IkappaBalpha protein] | phosphorylation at Ser32 and Ser36 | Homo sapiens | ADP + [IkappaBalpha phosphoprotein] | - |
? | |
| ATP + [IkappaBbeta protein] | phosphorylation at Ser19 and Ser23 | Mus musculus | ADP + [IkappaBbeta phosphoprotein] | - |
? | |
| ATP + [IkappaBbeta protein] | phosphorylation at Ser19 and Ser23 | Homo sapiens | ADP + [IkappaBbeta phosphoprotein] | - |
? | |
| additional information | IKKalpha, not IKKbeta, is required for epidermal regeneration, IkappaB kinases are essential key regulators of the canonical and noncanonical NFkappaB pathways important for the expression of a wide variety of genes that are involved in the control of immune and inflammatory response, and in the regulation of cellular proliferation and survival, mechanism, overview | Mus musculus | ? | - |
? | |
| additional information | IKKalpha, not IKKbeta, is required for epidermal regeneration, IkappaB kinases are essential key regulators of the canonical and noncanonical NFkappaB pathways important for the expression of a wide variety of genes that are involved in the control of immune and inflammatory response, and in the regulation of cellular proliferation and survival, mechanism, overview | Homo sapiens | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| More | the IKK complex consists of 3 subunits: catalytic IKKalpha and IKKbeta, and noncatalytic NEMO/IKKgamma | Homo sapiens |
| More | the IKK complex consists of 3 subunits: catalytic IKKalpha and IKKbeta, and noncatalytic, regulatory NEMO/IKKgamma | Mus musculus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| IKK | - |
Mus musculus |
| IKK | - |
Homo sapiens |
| inhibitor of kappaB kinase | - |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Mus musculus | |
| ATP | - |
Homo sapiens | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
