Literature summary for 2.7.11.10 extracted from

Lawrence, T.; Bebien, M.; Liu, G.Y.; Nizet, V.; Karin, M.
IKKalpha limits macrophage NF-kappaB activation and contributes to the resolution of inflammation (2005), Nature, 434, 1138-1143.

Search for more literature for 2.7.11.10

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytoplasm	-	Mus musculus	5737	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Mus musculus	subunit IKKbeta controls the activation of NF-kappaB, important in inflammation, IKKalpha plays a role in lyphoid organogenesis and suppresses NF-kappaB activity by accelerating both the turnover of the NFkappaB subunits RelA and c-Rel, and their removal from pro-inflammatory gene promoters, inactivation of IKKalpha enhances inflammation and bacterial clearance in mice, overview	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	wild-type and IKKalpha- mice	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
macrophage	alveolar and peritoneal	Mus musculus	-
MEF cell	embryonic fibroblast cell line, from wild-type and IKKalpha- mice	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + [IkappaBalpha protein]	IKKbeta-dependent phosphorylation and subsequent ubiquitin-dependent proteolytic degradation of IKKalpha, the 2 subunits have opposing function in NF-kappaB metabolism, overview	Mus musculus	ADP + [IkappaBalpha phosphoprotein]	-	?
additional information	subunit IKKbeta controls the activation of NF-kappaB, important in inflammation, IKKalpha plays a role in lyphoid organogenesis and suppresses NF-kappaB activity by accelerating both the turnover of the NFkappaB subunits RelA and c-Rel, and their removal from pro-inflammatory gene promoters, inactivation of IKKalpha enhances inflammation and bacterial clearance in mice, overview	Mus musculus	?	-	?

Subunits

Subunits	Comment	Organism
More	the IKK complex consists of 3 subunits: catalytic IKKalpha and IKKbeta, and noncatalytic NEMO/IKKgamma	Mus musculus

Synonyms

Synonyms	Comment	Organism
IKK	-	Mus musculus
IKK complex	-	Mus musculus

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Release 2023.1 (January 2023)