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Literature summary for 2.7.11.10 extracted from

  • Verma, U.N.; Yamamoto, Y.; Prajapati, S.; Gaynor, R.B.
    Nuclear role of IkappaB kinase-gamma/NF-kappaB essential modulator (IKK gamma/NEMO) in NF-kappaB-dependent gene expression (2004), J. Biol. Chem., 279, 3509-3515.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information IKK induction by cytokines, transcriptional activation by CREB-binding protein, i.e. CBP, after N-terminally binding to NEMO, which competes with IKKalpha and p65 Homo sapiens
NEMO i.e. NF-kappaB essential modifier, complexing with IkappaB kinase-gamma, regulates cytokine-induced IKK complex activity, NEMO/IKKgamma is shuttling between cytoplasm and nucleus, and binds CBP, being ininvolved in NFkappaB regulation Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
coexpression of Myc-tagged NEMO/IKKgamma, FLAG-tagged p65, and HA-tagged or GST-tagged CREB-binding protein in 293T cells or in mouse embryonic fibroblasts MEF cell line Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information CREB-binding protein-bound NEMO/IKKgamma inhibits IKKalpha and p65 transcriptional activities Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm IKK complex, NEMO/IKKgamma is shuttling between cytoplasm and nucleus Homo sapiens 5737
-
nucleus NEMO/IKKgamma is shuttling between cytoplasm and nucleus Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [GST-IkappaBalpha protein] Homo sapiens
-
ADP + [GST-IkappaBalpha phosphoprotein]
-
?
ATP + [histone H3 protein] Homo sapiens
-
ADP + [histone H3 phosphoprotein]
-
?
additional information Homo sapiens the IKK complex is responsible for NFkappaB regulation ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [GST-IkappaBalpha protein]
-
Homo sapiens ADP + [GST-IkappaBalpha phosphoprotein]
-
?
ATP + [histone H3 protein]
-
Homo sapiens ADP + [histone H3 phosphoprotein]
-
?
additional information the IKK complex is responsible for NFkappaB regulation Homo sapiens ?
-
?

Subunits

Subunits Comment Organism
More the IKK complex consists of 3 subunits: catalytic IKKalpha and IKKbeta, and noncatalytic, regulatory NEMO/IKKgamma Homo sapiens

Synonyms

Synonyms Comment Organism
IKK complex
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
Homo sapiens