Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | IKK induction by cytokines, transcriptional activation by CREB-binding protein, i.e. CBP, after N-terminally binding to NEMO, which competes with IKKalpha and p65 | Homo sapiens | |
NEMO | i.e. NF-kappaB essential modifier, complexing with IkappaB kinase-gamma, regulates cytokine-induced IKK complex activity, NEMO/IKKgamma is shuttling between cytoplasm and nucleus, and binds CBP, being ininvolved in NFkappaB regulation | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
coexpression of Myc-tagged NEMO/IKKgamma, FLAG-tagged p65, and HA-tagged or GST-tagged CREB-binding protein in 293T cells or in mouse embryonic fibroblasts MEF cell line | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | CREB-binding protein-bound NEMO/IKKgamma inhibits IKKalpha and p65 transcriptional activities | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | IKK complex, NEMO/IKKgamma is shuttling between cytoplasm and nucleus | Homo sapiens | 5737 | - |
nucleus | NEMO/IKKgamma is shuttling between cytoplasm and nucleus | Homo sapiens | 5634 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [GST-IkappaBalpha protein] | Homo sapiens | - |
ADP + [GST-IkappaBalpha phosphoprotein] | - |
? | |
ATP + [histone H3 protein] | Homo sapiens | - |
ADP + [histone H3 phosphoprotein] | - |
? | |
additional information | Homo sapiens | the IKK complex is responsible for NFkappaB regulation | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HeLa cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [GST-IkappaBalpha protein] | - |
Homo sapiens | ADP + [GST-IkappaBalpha phosphoprotein] | - |
? | |
ATP + [histone H3 protein] | - |
Homo sapiens | ADP + [histone H3 phosphoprotein] | - |
? | |
additional information | the IKK complex is responsible for NFkappaB regulation | Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | the IKK complex consists of 3 subunits: catalytic IKKalpha and IKKbeta, and noncatalytic, regulatory NEMO/IKKgamma | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
IKK complex | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |