Literature summary for 2.7.11.10 extracted from

Carter, R.S.; Pennington, K.N.; Ungurait, B.J.; Ballard, D.W.
In vivo identification of inducible phosphoacceptors in the IKKgamma/NEMO subunit of human IkappaB kinase (2003), J. Biol. Chem., 278, 19642-19648.

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Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	IKKgamma phosphorylation by IKKbeta is induced by the cytokine TNFalpha and the viral oncoprotein Tax	Homo sapiens
NEMO	i.e. NF-kappaB essential modifier, complexing with IkappaB kinase-gamma and ubiquination, involving the zinc finger of NEMO and c-IAP1, are required for activation of the IkappaB kinase complex by inflammatory stimuli such as tumor necrosis factor TNFalpha	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
coexpression of FLAG-tagged IKKbeta, T7-tagged IKKgamma, and Tax in 293T cells and in murine embryonic fibroblasts devoid of the enzyme	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
additional information	mutations of X-linked gene encoding IKKgamma can lead to immunodeficiency diseases interfering with NFkappaB-signaling	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytoplasm	-	Homo sapiens	5737	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Homo sapiens	IKK marks cytoplasmic NFkappaB inhibitors for proteolytic destruction playing a role in regulation of genetic cell cycle programs, IKK regulates nuclear translocation of transcription factor NFkappaB	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	IKK-1 and IKK-2	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
phosphoprotein	subunit IKKgamma is activated by phosphorylation via IKKbeta subunit at Ser31, Ser43, and Ser376, IKKgamma phosphorylation requires its zinc finger sequence at the C-terminus, phosphopeptide mapping	Homo sapiens

Reaction

Reaction	Comment	Organism	Reaction ID
ATP + [IkappaB protein] = ADP + [IkappaB phosphoprotein]	activation and reaction mechanism	Homo sapiens	a

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + [GST-IkappaBalpha protein]	-	Homo sapiens	ADP + [GST-IkappaBalpha phosphoprotein]	-	?
additional information	IKK marks cytoplasmic NFkappaB inhibitors for proteolytic destruction playing a role in regulation of genetic cell cycle programs, IKK regulates nuclear translocation of transcription factor NFkappaB	Homo sapiens	?	-	?

Subunits

Subunits	Comment	Organism
More	the IKK complex consists of 3 subunits: catalytic IKKalpha and IKKbeta, and noncatalytic NEMO/IKKgamma	Homo sapiens

Synonyms

Synonyms	Comment	Organism
IKK	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Homo sapiens

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Release 2023.1 (January 2023)