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Literature summary for 2.7.11.1 extracted from

  • Yan, Q.; Jiang, D.; Qian, L.; Zhang, Q.; Zhang, W.; Zhou, W.; Mi, K.; Guddat, L.; Yang, H.; Rao, Z.
    Structural insight into the activation of PknI kinase from M.xa0tuberculosis via dimerization of the extracellular sensor domain (2017), Structure, 25, 1286-1294.e4 .
    View publication on PubMed
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Activating Compound

Activating Compound Comment Organism Structure
additional information activation of PknI kinase from Mycobacteriumxa0tuberculosis via dimerization of the extracellular sensor domain Mycobacterium tuberculosis

Cloned(Commentary)

Cloned (Comment) Organism
fusion proteins expressed in Escherichia coli Mycobacterium tuberculosis

Crystallization (Commentary)

Crystallization (Comment) Organism
vapor diffusion method, crystal structures of PknI sensor domain (PknI_SD) monomer and dimer, as well as PknI kinase domain (PknI_KD) Mycobacterium tuberculosis

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis P9WI69
-
-
Mycobacterium tuberculosis H37Rv P9WI69
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein simulated PknI_KJD dimerization activates kinase autophosphorylation activity Mycobacterium tuberculosis

Purification (Commentary)

Purification (Comment) Organism
-
 Mycobacterium tuberculosis

Subunits

Subunits Comment Organism
dimer PknI sensor domain (PknI_SD) adopts two conformations in solution: monomer and dimer Mycobacterium tuberculosis
monomer PknI sensor domain (PknI_SD) adopts two conformations in solution: monomer and dimer Mycobacterium tuberculosis

Synonyms

Synonyms Comment Organism
PknI
-
 Mycobacterium tuberculosis

General Information

General Information Comment Organism
physiological function the enzyme is required for regulating Mycobacterium tuberculosis growth within macrophage Mycobacterium tuberculosis