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Literature summary for 2.7.11.1 extracted from

  • Eng, G.; Ediso, E.; Virshup, D.
    Site-specific phosphorylation of casein kinase 1 delta (CK1delta) regulates its activity towards the circadian regulator PER2 (2017), PLoS ONE, 12, e0177834 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.1

Protein Variants

Protein Variants Comment Organism
S347A non-phosphorylatable mutant enzyme of CK1delta exhibits higher specific activity on PER2 protein Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + PER2 protein Mus musculus S659A mutation sensitizes PER2 to CK1delta mediated degradation ADP + phosphorylated PER2 protein
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 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
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Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein regulation of CK1delta activity by proline-directed kinases. Relevance of this regulation in the control of a key CK1delta substrate, the PER2 protein Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + PER2 protein S659A mutation sensitizes PER2 to CK1delta mediated degradation Mus musculus ADP + phosphorylated PER2 protein
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 ?
ATP + PER2 protein the enzyme phosphorylates PER2 in two sites, the FASP site and the beta-TrCP site Mus musculus ADP + phosphorylated PER2 protein
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 ?

Synonyms

Synonyms Comment Organism
casein kinase 1delta
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 Mus musculus
CK1delta
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 Mus musculus
CSNK1D
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 Mus musculus

General Information

General Information Comment Organism
physiological function the enzyme (CK1delta) is the key regulator of circadian rhythms in vivo Mus musculus