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Literature summary for 2.7.11.1 extracted from

  • Kato, K.; Sugi, T.; Takemae, H.; Takano, R.; Gong, H.; Ishiwa, A.; Horimoto, T.; Akashi, H.
    Characterization of a Toxoplasma gondii calcium calmodulin-dependent protein kinase homolog (2016), Parasit. Vectors, 9, 405 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.1

Activating Compound

Activating Compound Comment Organism Structure
additional information calmodulin is not required for the protein kinase activity. Calmodulin antagonists like W-7 or calmidazolium have no effect on enzyme kinase activity Toxoplasma gondii

Cloned(Commentary)

Cloned (Comment) Organism
expressed in a wheat germ cell-free protein synthesis system Toxoplasma gondii

Metals/Ions

Metals/Ions Comment Organism Structure
additional information Ca2+ is not required for the protein kinase activity Toxoplasma gondii

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
121000
-
 gel filtration Toxoplasma gondii

Organism

Organism UniProt Comment Textmining
Toxoplasma gondii H3K408
-
-
Toxoplasma gondii RH H3K408
-
-

Purification (Commentary)

Purification (Comment) Organism
glutathione-Sepharose bead chromatography Toxoplasma gondii

Source Tissue

Source Tissue Comment Organism Textmining
tachyzoite the enzyme localizes to the apical ends of extracellular and intracellular tachyzoites Toxoplasma gondii
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + GAP45 protein the enzyme phosphorylates GAP45 protein at Ser163 and Ser167 Toxoplasma gondii ADP + phosphorylated GAP45 protein
-
 ?
ATP + GAP45 protein the enzyme phosphorylates GAP45 protein at Ser163 and Ser167 Toxoplasma gondii RH ADP + phosphorylated GAP45 protein
-
 ?
ATP + histone
-
 Toxoplasma gondii ADP + phosphorylated histone
-
 ?
ATP + histone
-
 Toxoplasma gondii RH ADP + phosphorylated histone
-
 ?
additional information the enzyme exhibits calmodulin-independent autophosphorylation and substrate phosphorylation activity Toxoplasma gondii ?
-
-
additional information the enzyme exhibits calmodulin-independent autophosphorylation and substrate phosphorylation activity Toxoplasma gondii RH ?
-
-

Synonyms

Synonyms Comment Organism
CaMK-related kinase
-
 Toxoplasma gondii
CaMKrk
-
 Toxoplasma gondii