Literature summary for 2.7.11.1 extracted from

Kearney, A.; Cooke, K.; Norris, D.; Zadoorian, A.; Krycer, J.; Fazakerley, D.; Burchfield, J.; James, D.
Serine 474 phosphorylation is essential for maximal Akt2 kinase activity in adipocytes (2019), J. Biol. Chem., 294, 16729-16739 .

Search for more literature for 2.7.11.1

Cloned(Commentary)

Cloned (Comment)	Organism
-	Mus musculus

Protein Variants

Protein Variants	Comment	Organism
W80A	the mutation confers resistance to the Akt inhibitor MK2206	Mus musculus

Inhibitors

Inhibitors	Comment	Organism	Structure
MK2206	W80A mutation confers resistance to the Akt inhibitor MK2206	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	Q60823	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
phosphoprotein	Serine 474 phosphorylation is essential for maximal Akt2 kinase activity in adipocytes. Ser474 phosphorylation is a driver of Akt substrate specificity	Mus musculus

Source Tissue

Source Tissue	Comment	Organism	Textmining
3T3-L1 cell	-	Mus musculus	-
adipocyte	-	Mus musculus	-

Synonyms

Synonyms	Comment	Organism
AKT2	-	Mus musculus

General Information

General Information	Comment	Organism
physiological function	the enzyme regulates essential biological processes such as cell survival, growth, and metabolism	Mus musculus

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Release 2023.1 (January 2023)