Protein Variants | Comment | Organism |
---|---|---|
S47D | the mutant enzyme inhibits cell migration and promotes cell proliferation | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q00535 | - |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | phosphorylation of the phosphoregulatory site S47 abolishes CDK5-p35 binding and renders the kinase catalytically inactive | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + p35 | - |
Homo sapiens | ADP + phosphorylated p35 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Cdk5 | - |
Homo sapiens |
cyclin-dependent kinase 5 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
evolution | S47 in CDK5 is evolutionarily conserved with a serine at this position in human, bovine, rat, mouse and Drosophila CDK5 and a substitution with threonine in yeast | Homo sapiens |
malfunction | overactivation of the enzyme (CDK5) has been implicated in several pathologies including neurodegeneration, cancer cell metastasis and type II diabetes | Homo sapiens |
physiological function | the enzyme (CDK5) is essential for embryonic development | Homo sapiens |