Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
colorectal cancer cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
casein kinase 2alpha | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
drug target | anti-cancer drug resistance restricts the efficacy of chemotherapy in malignant tumors. Casein kinase 2alpha (CK2alpha) is highly expressed in 5-fluorouracil (5FU)-resistant colorectal cancer cells. Casein kinase 2alpha enhances 5-fluorouracil resistance in colorectal cancer cells by inhibiting endoplasmic reticulum stress. 5FU treatment in combination with a CK2alpah inhibitor may exert a synergistic effect against drug-resistant cancer cells | Homo sapiens |