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Literature summary for 2.7.11.1 extracted from

  • Kim, H.; Han, Y.; Lee, J.; Lee, S.
    Casein kinase 2alpha enhances 5-fluorouracil resistance in colorectal cancer cells by inhibiting endoplasmic reticulum stress (2020), Anticancer Res., 40, 1419-1426 .
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
colorectal cancer cell
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Homo sapiens
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Synonyms

Synonyms Comment Organism
casein kinase 2alpha
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Homo sapiens

General Information

General Information Comment Organism
drug target anti-cancer drug resistance restricts the efficacy of chemotherapy in malignant tumors. Casein kinase 2alpha (CK2alpha) is highly expressed in 5-fluorouracil (5FU)-resistant colorectal cancer cells. Casein kinase 2alpha enhances 5-fluorouracil resistance in colorectal cancer cells by inhibiting endoplasmic reticulum stress. 5FU treatment in combination with a CK2alpah inhibitor may exert a synergistic effect against drug-resistant cancer cells Homo sapiens