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Literature summary for 2.7.11.1 extracted from

  • Fu, G.; Wei, Y.; Wang, X.; Yu, L.
    Phosphorylated testis-specific serine/threonine kinase 4 may phosphorylate Crem at Ser-117 (2016), Biosci. Biotechnol. Biochem., 80, 1088-1094 .
No PubMed abstract available

Activating Compound

Activating Compound Comment Organism Structure
additional information the enzyme is activated by phosphorylation Mus musculus

Cloned(Commentary)

Cloned (Comment) Organism
gene Tssk4, recombinant expression of GST-tagged Tssk4 in Escherichia coli strain BL21 Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information construction of a kinase-dead mutant Tssk4M Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + Cre-responsive element modulator Mus musculus Tssk-4 phosphorylates Cre-responsive element modulator, Crem, at Ser117 ADP + phospho-Crem
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?

Organism

Organism UniProt Comment Textmining
Mus musculus Q9D411
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-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein the enzyme is activated by phosphorylation Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
testis the enzyme Tssk4 exists both in phosphorylated and unphosphorylated status dependent on the developmental status of testis. Colocalization with the Cre-responsive element modulator, Crem, in testis, but not with Cre-responsive element binding, Creb Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + Cre-responsive element modulator Tssk-4 phosphorylates Cre-responsive element modulator, Crem, at Ser117 Mus musculus ADP + phospho-Crem
-
?
ATP + Cre-responsive element modulator Tssk-4 phosphorylates Cre-responsive element modulator, Crem, at Ser117, Crem-S117A mutant is no substrate Mus musculus ADP + phospho-Crem
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?

Synonyms

Synonyms Comment Organism
testis-specific kinase 4 UniProt Mus musculus
testis-specific serine/threonine kinase 4
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Mus musculus
TSK-4 UniProt Mus musculus
Tssk
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Mus musculus
TSSK-4 UniProt Mus musculus

Cofactor

Cofactor Comment Organism Structure
ATP
-
Mus musculus

General Information

General Information Comment Organism
evolution the enzyme is a Tssk family member Mus musculus
physiological function phosphorylated/activated testis-specific serine/threonine kinase 4 phosphorylates Crem at Ser117. Phosphorylated Tssk4 might be involved in the process of spermatogenesis Mus musculus