Literature summary for 2.7.11.1 extracted from
Fu, G.; Wei, Y.; Wang, X.; Yu, L.
Phosphorylated testis-specific serine/threonine kinase 4 may phosphorylate Crem at Ser-117 (2016), Biosci. Biotechnol. Biochem., 80, 1088-1094 .
No PubMed abstract available
Activating Compound
Activating Compound |
Comment |
Organism |
Structure |
additional information |
the enzyme is activated by phosphorylation |
Mus musculus |
|
Cloned(Commentary)
Cloned (Comment) |
Organism |
gene Tssk4, recombinant expression of GST-tagged Tssk4 in Escherichia coli strain BL21 |
Mus musculus |
Protein Variants
Protein Variants |
Comment |
Organism |
additional information |
construction of a kinase-dead mutant Tssk4M |
Mus musculus |
Natural Substrates/ Products (Substrates)
Natural Substrates |
Organism |
Comment (Nat. Sub.) |
Natural Products |
Comment (Nat. Pro.) |
Rev. |
Reac. |
ATP + Cre-responsive element modulator |
Mus musculus |
Tssk-4 phosphorylates Cre-responsive element modulator, Crem, at Ser117 |
ADP + phospho-Crem |
- |
? |
|
Organism
Organism |
UniProt |
Comment |
Textmining |
Mus musculus |
Q9D411 |
- |
- |
Posttranslational Modification
Posttranslational Modification |
Comment |
Organism |
phosphoprotein |
the enzyme is activated by phosphorylation |
Mus musculus |
Source Tissue
Source Tissue |
Comment |
Organism |
Textmining |
testis |
the enzyme Tssk4 exists both in phosphorylated and unphosphorylated status dependent on the developmental status of testis. Colocalization with the Cre-responsive element modulator, Crem, in testis, but not with Cre-responsive element binding, Creb |
Mus musculus |
- |
Substrates and Products (Substrate)
Substrates |
Comment Substrates |
Organism |
Products |
Comment (Products) |
Rev. |
Reac. |
ATP + Cre-responsive element modulator |
Tssk-4 phosphorylates Cre-responsive element modulator, Crem, at Ser117 |
Mus musculus |
ADP + phospho-Crem |
- |
? |
|
ATP + Cre-responsive element modulator |
Tssk-4 phosphorylates Cre-responsive element modulator, Crem, at Ser117, Crem-S117A mutant is no substrate |
Mus musculus |
ADP + phospho-Crem |
- |
? |
|
Synonyms
Synonyms |
Comment |
Organism |
testis-specific kinase 4 |
UniProt |
Mus musculus |
testis-specific serine/threonine kinase 4 |
- |
Mus musculus |
TSK-4 |
UniProt |
Mus musculus |
Tssk |
- |
Mus musculus |
TSSK-4 |
UniProt |
Mus musculus |
Cofactor
Cofactor |
Comment |
Organism |
Structure |
ATP |
- |
Mus musculus |
|
General Information
General Information |
Comment |
Organism |
evolution |
the enzyme is a Tssk family member |
Mus musculus |
physiological function |
phosphorylated/activated testis-specific serine/threonine kinase 4 phosphorylates Crem at Ser117. Phosphorylated Tssk4 might be involved in the process of spermatogenesis |
Mus musculus |