Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + AMP-activated protein kinase | Mus musculus | - |
ADP + phosphorylated AMP-activated protein kinase | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
additional information | LKB1 is expressed in multiple tissues | Mus musculus | - |
spleen | - |
Mus musculus | - |
thymocyte | - |
Mus musculus | - |
thymus | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + AMP-activated protein kinase | - |
Mus musculus | ADP + phosphorylated AMP-activated protein kinase | - |
? |
Synonyms | Comment | Organism |
---|---|---|
LKB1 | - |
Mus musculus |
Ser/Thr kinase | - |
Mus musculus |
serine/threonine kinase | - |
Mus musculus |
STK11 | - |
Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | LKB1-deficient mice exhibit a developmental block at the double-negative cell stage DN3 to DN4 transition. T-cell-specific deletion of LKB1 results in reduced survival of double-positive thymocytes and impaired generation of both CD4 and CD8 single-positive thymocytes. Disruption of LKB1 not only prevents the activation of AMPK but also impairs the expression of anti-apoptotic protein Bcl-XL. Ectopic expression of either Bcl-XL or the constitutively active AMPK mutant T172D significantly rescues double-positive thymocytes from LKB1 deficiency-induced cell death. Ectopic expression of the constitutively active AMPK mutant restores the expression of Bcl-XL in LKB1-deficient double-positive thymocytes | Mus musculus |
metabolism | the serine/threonine kinase LKB1 is the main upstream kinase of the AMP-activated protein kinase cascade that senses cellular energy state and adjusts cellular metabolism | Mus musculus |
physiological function | LKB1 is a serine/threonine kinase that directly activates the energy sensor AMP-activated protein kinase in response to bioenergetic stress, to rising AMP:ATP ratio, and mainly acts as a tumor suppressor that controls cell polarity and proliferation. Cell phenotypes,overview | Mus musculus |