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Literature summary for 2.7.11.1 extracted from

  • Cao, Y.; Li, H.; Liu, H.; Zheng, C.; Ji, H.; Liu, X.
    The serine/threonine kinase LKB1 controls thymocyte survival through regulation of AMPK activation and Bcl-XL expression (2010), Cell Res., 20, 99-108.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + AMP-activated protein kinase Mus musculus
-
ADP + phosphorylated AMP-activated protein kinase
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
additional information LKB1 is expressed in multiple tissues Mus musculus
-
spleen
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Mus musculus
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thymocyte
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Mus musculus
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thymus
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Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + AMP-activated protein kinase
-
Mus musculus ADP + phosphorylated AMP-activated protein kinase
-
?

Synonyms

Synonyms Comment Organism
LKB1
-
Mus musculus
Ser/Thr kinase
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Mus musculus
serine/threonine kinase
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Mus musculus
STK11
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Mus musculus

Cofactor

Cofactor Comment Organism Structure
ATP
-
Mus musculus

General Information

General Information Comment Organism
malfunction LKB1-deficient mice exhibit a developmental block at the double-negative cell stage DN3 to DN4 transition. T-cell-specific deletion of LKB1 results in reduced survival of double-positive thymocytes and impaired generation of both CD4 and CD8 single-positive thymocytes. Disruption of LKB1 not only prevents the activation of AMPK but also impairs the expression of anti-apoptotic protein Bcl-XL. Ectopic expression of either Bcl-XL or the constitutively active AMPK mutant T172D significantly rescues double-positive thymocytes from LKB1 deficiency-induced cell death. Ectopic expression of the constitutively active AMPK mutant restores the expression of Bcl-XL in LKB1-deficient double-positive thymocytes Mus musculus
metabolism the serine/threonine kinase LKB1 is the main upstream kinase of the AMP-activated protein kinase cascade that senses cellular energy state and adjusts cellular metabolism Mus musculus
physiological function LKB1 is a serine/threonine kinase that directly activates the energy sensor AMP-activated protein kinase in response to bioenergetic stress, to rising AMP:ATP ratio, and mainly acts as a tumor suppressor that controls cell polarity and proliferation. Cell phenotypes,overview Mus musculus