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Literature summary for 2.7.11.1 extracted from

  • Duffy, P.; Schmandke, A.; Schmandke, A.; Sigworth, J.; Narumiya, S.; Cafferty, W.B.; Strittmatter, S.M.
    Rho-associated kinase II (ROCKII) limits axonal growth after trauma within the adult mouse spinal cord (2009), J. Neurosci., 29, 15266-15276.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Mus musculus
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-
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Source Tissue

Source Tissue Comment Organism Textmining
brain
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Mus musculus
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spinal cord
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Mus musculus
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Synonyms

Synonyms Comment Organism
Rho-associated kinase II
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Mus musculus
ROCKII
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Mus musculus

General Information

General Information Comment Organism
malfunction ROCKII knockout mice develop with impaired motor function, ROCKII-deficient dorsal root ganglion neurons are less sensitive to inhibition by Nogo protein or by chondroitin sulfate proteoglycan in vitro, after dorsal root crush injury, the ROCKII-deficient mice recover use of the affected forepaw more quickly than do controls, after the spinal cord injury ROCKII-deficient mice show enhanced local growth of raphespinal axons in the caudal spinal cord and corticospinal axons into the lesion site Mus musculus