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Literature summary for 2.7.11.1 extracted from

  • Hanger, D.P.; Byers, H.L.; Wray, S.; Leung, K.Y.; Saxton, M.J.; Seereeram, A.; Reynolds, C.H.; Ward, M.A.; Anderton, B.H.
    Novel phosphorylation sites in tau from Alzheimer brain support a role for casein kinase 1 in disease pathogenesis (2007), J. Biol. Chem., 282, 23645-23654.
    View publication on PubMed

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + tau protein Homo sapiens tau in Alzheimer disease brain is highly phosphorylated and aggregates into paired helical filaments comprising characteristic neurofibrillary tangles, overview ADP + phosphorylated tau protein
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
isozyme CKIdelta
-

Source Tissue

Source Tissue Comment Organism Textmining
brain from Alzheimer patients, isozyme CKIdelta Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + tau protein tau in Alzheimer disease brain is highly phosphorylated and aggregates into paired helical filaments comprising characteristic neurofibrillary tangles, overview Homo sapiens ADP + phosphorylated tau protein
-
?
ATP + tau protein determination of several phosphorylation sites, e.g. Ser258, Ser289, Ser262, and Ser356 within the microtubule-binding repeats or at Ser184 and Ser185 of the central region, for casein kinase I, casein kinase 2, and glycogen synthase kinase-3beta in insoluble tau, PHF-tau, extracted from Alzheimer brain and of tau from control healthy brain by mass spectrometry, overview Homo sapiens ADP + phosphorylated tau protein
-
?

Synonyms

Synonyms Comment Organism
casein kinase 1
-
Homo sapiens
casein kinase 2
-
Homo sapiens
CK1
-
Homo sapiens
CK2
-
Homo sapiens
glycogen synthase kinase-3beta
-
Homo sapiens
GSK-3beta
-
Homo sapiens
More cf. EC 2.7.11.26 Homo sapiens
Tau-tubulin kinase 1
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
assay at Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
Homo sapiens