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Literature summary for 2.7.11.1 extracted from
- Ribosomal S6 kinase 2 is a key regulator in tumor promoter induced cell transformation (2007), Cancer Res., 67, 8104-8112.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | RSK2 is activated by phosphorylation by extracellular signal-regulated kinase 1/2 and phosphoinositide-dependent kinase 1 in response to many growth factors and peptide hormones | Mus musculus |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| ectopic overexpression of RSK2 in MEF cells induces anchorage-independent cell transformation | Mus musculus |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | knockdown of RSK2 by siRNA expression in NIH3T3 cells blocks foci formation, overview | Mus musculus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| kaempferol | an inhibitor of RSK2 invitro and in vivo, and suppresses proliferation and EGF-induced transformation in JB6 Cl41 cells, overview | Mus musculus |  |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| nucleus | - |
Mus musculus | 5634 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | - |
Mus musculus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + histone H3 | Mus musculus | RSK2 is a key regulator of histone H3 phosphorylation | ADP + phosphorylated histone H3 | - |
? | |
| additional information | Mus musculus | RSK2 is a critical serine/threonine kinase for the regulation of cell transformation, RSK is regulated by the tumor promoters epidermal growth factor EGF or 12-O-tetradecanoylphorbol-13-acetate, TPA, overview | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| phosphoprotein | RSK2 is activated by phosphorylation by extracellular signal-regulated kinase 1/2 and phosphoinositide-dependent kinase 1 in response to many growth factors and peptide hormones | Mus musculus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| fibroblast | - |
Mus musculus | - |
| JB6 Cl41 cell | - |
Mus musculus | - |
| MEF cell | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + GST-CREB2 protein | - |
Mus musculus | ADP + phosphorylated GST-CREB2 protein | - |
? | |
| ATP + GST-NFAT3D4-261-365 | - |
Mus musculus | ADP + phosphorylated GST-NFAT3D4-261-365 | - |
? | |
| ATP + histone H3 | - |
Mus musculus | ADP + phosphorylated histone H3 | - |
? | |
| ATP + histone H3 | RSK2 is a key regulator of histone H3 phosphorylation | Mus musculus | ADP + phosphorylated histone H3 | - |
? | |
| additional information | RSK2 is a critical serine/threonine kinase for the regulation of cell transformation, RSK is regulated by the tumor promoters epidermal growth factor EGF or 12-O-tetradecanoylphorbol-13-acetate, TPA, overview | Mus musculus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| More | the enzyme belongs to the p90RSK, RSK, family of proteins | Mus musculus |
| ribosomal S6 kinase 2 | - |
Mus musculus |
| RSK2 | - |
Mus musculus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 30 | - |
assay at | Mus musculus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Mus musculus | |
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