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Literature summary for 2.7.11.1 extracted from

  • Auer, A.; von Blume, J.; Sturany, S.; von Wichert, G.; Van Lint, J.; Vandenheede, J.; Adler, G.; Seufferlein, T.
    Role of the regulatory domain of protein kinase D2 in phorbol ester binding, catalytic activity, and nucleocytoplasmic shuttling (2005), Mol. Biol. Cell, 16, 4375-4385.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.1

Activating Compound

Activating Compound Comment Organism Structure
gastrin bind to the cysteine-rich domain C1b, activates, triggers nuclear accumulation of PPKD2 in AGS-B cancer cells Homo sapiens
additional information PKD2 is activated via G protein-coupled receptors Homo sapiens
Phorbol esters bind to the cysteine-rich domain C1b Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expression of EGFP- or FLAG-tagged wild-type or domain-deletion mutants of PKD2 in HEK-293 cells, gastric cancer AGS-B cells, and in PANC-1 cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information the pleckstrin homology PH domain is a negative regulator of PKD2 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Homo sapiens 5737
-
additional information nucleocytoplasmic shuttling regulated by a CRm-1-dependent mechanism, involving the C1b domain, and the C1a domain containing a nuclear export signal sequence Homo sapiens
-
-
nucleus
-
 Homo sapiens 5634
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens PKD2 regulation involving ligand-binding domains of the enzyme, isozyme PKD2 might play a role in the nucleus after activation by G protein-coupled receptors, overview, intracellular trafficking of PKD2, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein PKD2 performs autophosphorylation Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + histone H1 PDK2 Homo sapiens ADP + phosphorylated histone H1
-
 ?
additional information PKD2 regulation involving ligand-binding domains of the enzyme, isozyme PKD2 might play a role in the nucleus after activation by G protein-coupled receptors, overview, intracellular trafficking of PKD2, overview Homo sapiens ?
-
 ?
additional information PKD2 performs autophosphorylation Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
More PKD2 belongs to the PKD family of serine/threonine kinases Homo sapiens
PKD2
-
 Homo sapiens
protein kinase D2
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens