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Literature summary for 2.7.11.1 extracted from

  • Zhang, Y.; Li, H.L.; Wang, D.L.; Liu, S.J.; Wang, J.Z.
    A transitory activation of protein kinase-A induces a sustained tau hyperphosphorylation at multiple sites in N2a cells-imply a new mechanism in Alzheimer pathology (2006), J. Neural Transm., 2, 1-11.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information forskolin has no effect on GSK-3 Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Neuro2a cells Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
microtubule
-
Homo sapiens 5874
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [tau-protein] Homo sapiens
-
ADP + O-phospho-[tau-protein]
-
?
additional information Homo sapiens GSK3beta works coordinatedly with PKA, EC 2.7.11.11, on tau phosphorylation ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + phosphoglycogen synthase peptide 2
-
Homo sapiens ADP + phosphorylated phosphoglycogen synthase peptide 2
-
?
ATP + [tau-protein]
-
Homo sapiens ADP + O-phospho-[tau-protein]
-
?
additional information GSK3beta works coordinatedly with PKA, EC 2.7.11.11, on tau phosphorylation Homo sapiens ?
-
?
additional information GSK3beta catalyzes tau phosphorylation in brain, EC 2.7.11.26, but phosphorylation of glycogen synthase and other proteins in different tissues Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
glycogen synthase kinase-3
-
Homo sapiens
GSK-3
-
Homo sapiens
More see also EC 2.7.11.26 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
Homo sapiens