Activating Compound | Comment | Organism | Structure |
---|---|---|---|
KbpA | an AfsK-binding protein activates and modulates the enzyme activity | Streptomyces coelicolor |
Cloned (Comment) | Organism |
---|---|
expression of AsfK and AsfR in Escherichia coli, expression of PkaG and SCD10.09 in Escherichia coli | Streptomyces coelicolor |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
K-252a | - |
Streptomyces coelicolor | |
staurosporine | - |
Streptomyces coelicolor |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Streptomyces coelicolor |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + AfsR protein | Streptomyces coelicolor | kinase AfsK specifically phosphorylates AfsR, a transcriptional activator with ATPase activity, starting a signal transduction pathway via induction of AfsS expression, thereby controlling the secondary metabolism of the bacterium, overview | ADP + AfsR phosphoprotein | - |
? | |
ATP + AfsR protein | Streptomyces coelicolor A3(2) | kinase AfsK specifically phosphorylates AfsR, a transcriptional activator with ATPase activity, starting a signal transduction pathway via induction of AfsS expression, thereby controlling the secondary metabolism of the bacterium, overview | ADP + AfsR phosphoprotein | - |
? | |
additional information | Streptomyces coelicolor | AfsK is a Hanks-type protein kinase | ? | - |
? | |
additional information | Streptomyces coelicolor A3(2) | AfsK is a Hanks-type protein kinase | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Streptomyces coelicolor | - |
gene afsK | - |
Streptomyces coelicolor A3(2) | - |
gene afsK | - |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | AfsK is autophosphorylated at serine and threonine residues leading to its activation, PkaG and SCD10.09 are autophosphorylated at serine and threonine residues | Streptomyces coelicolor |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + AfsR protein | kinase AfsK specifically phosphorylates AfsR, a transcriptional activator with ATPase activity, starting a signal transduction pathway via induction of AfsS expression, thereby controlling the secondary metabolism of the bacterium, overview | Streptomyces coelicolor | ADP + AfsR phosphoprotein | - |
? | |
ATP + AfsR protein | phosphorylation of serine and threonine residues by activated kinase AfsK, and by PkaG and SCD10.09, the Streptomyces coelicolor strain A3(2) contains more than 40 enzymes phosphorylating the substrate AsfR | Streptomyces coelicolor | ADP + AfsR phosphoprotein | - |
? | |
ATP + AfsR protein | kinase AfsK specifically phosphorylates AfsR, a transcriptional activator with ATPase activity, starting a signal transduction pathway via induction of AfsS expression, thereby controlling the secondary metabolism of the bacterium, overview | Streptomyces coelicolor A3(2) | ADP + AfsR phosphoprotein | - |
? | |
ATP + AfsR protein | phosphorylation of serine and threonine residues by activated kinase AfsK, and by PkaG and SCD10.09, the Streptomyces coelicolor strain A3(2) contains more than 40 enzymes phosphorylating the substrate AsfR | Streptomyces coelicolor A3(2) | ADP + AfsR phosphoprotein | - |
? | |
additional information | AfsK is a Hanks-type protein kinase | Streptomyces coelicolor | ? | - |
? | |
additional information | AfsK, PkaG, and SCD10 perform autophosphorylation | Streptomyces coelicolor | ? | - |
? | |
additional information | AfsK is a Hanks-type protein kinase | Streptomyces coelicolor A3(2) | ? | - |
? | |
additional information | AfsK, PkaG, and SCD10 perform autophosphorylation | Streptomyces coelicolor A3(2) | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AsfK | - |
Streptomyces coelicolor |
PkaG | - |
Streptomyces coelicolor |
SCD10.09 | - |
Streptomyces coelicolor |
serine/threonine kinase | - |
Streptomyces coelicolor |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Streptomyces coelicolor |