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Literature summary for 2.7.11.1 extracted from

  • Horinouchi, S.
    AfsR as an integrator of signals that are sensed by multiple serine/threonine kinases in Streptomyces coelicolor A3(2) (2003), J. Ind. Microbiol. Biotechnol., 30, 462-467.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
KbpA an AfsK-binding protein activates and modulates the enzyme activity Streptomyces coelicolor

Cloned(Commentary)

Cloned (Comment) Organism
expression of AsfK and AsfR in Escherichia coli, expression of PkaG and SCD10.09 in Escherichia coli Streptomyces coelicolor

Inhibitors

Inhibitors Comment Organism Structure
K-252a
-
Streptomyces coelicolor
staurosporine
-
Streptomyces coelicolor

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
Streptomyces coelicolor

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + AfsR protein Streptomyces coelicolor kinase AfsK specifically phosphorylates AfsR, a transcriptional activator with ATPase activity, starting a signal transduction pathway via induction of AfsS expression, thereby controlling the secondary metabolism of the bacterium, overview ADP + AfsR phosphoprotein
-
?
ATP + AfsR protein Streptomyces coelicolor A3(2) kinase AfsK specifically phosphorylates AfsR, a transcriptional activator with ATPase activity, starting a signal transduction pathway via induction of AfsS expression, thereby controlling the secondary metabolism of the bacterium, overview ADP + AfsR phosphoprotein
-
?
additional information Streptomyces coelicolor AfsK is a Hanks-type protein kinase ?
-
?
additional information Streptomyces coelicolor A3(2) AfsK is a Hanks-type protein kinase ?
-
?

Organism

Organism UniProt Comment Textmining
Streptomyces coelicolor
-
gene afsK
-
Streptomyces coelicolor A3(2)
-
gene afsK
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein AfsK is autophosphorylated at serine and threonine residues leading to its activation, PkaG and SCD10.09 are autophosphorylated at serine and threonine residues Streptomyces coelicolor

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + AfsR protein kinase AfsK specifically phosphorylates AfsR, a transcriptional activator with ATPase activity, starting a signal transduction pathway via induction of AfsS expression, thereby controlling the secondary metabolism of the bacterium, overview Streptomyces coelicolor ADP + AfsR phosphoprotein
-
?
ATP + AfsR protein phosphorylation of serine and threonine residues by activated kinase AfsK, and by PkaG and SCD10.09, the Streptomyces coelicolor strain A3(2) contains more than 40 enzymes phosphorylating the substrate AsfR Streptomyces coelicolor ADP + AfsR phosphoprotein
-
?
ATP + AfsR protein kinase AfsK specifically phosphorylates AfsR, a transcriptional activator with ATPase activity, starting a signal transduction pathway via induction of AfsS expression, thereby controlling the secondary metabolism of the bacterium, overview Streptomyces coelicolor A3(2) ADP + AfsR phosphoprotein
-
?
ATP + AfsR protein phosphorylation of serine and threonine residues by activated kinase AfsK, and by PkaG and SCD10.09, the Streptomyces coelicolor strain A3(2) contains more than 40 enzymes phosphorylating the substrate AsfR Streptomyces coelicolor A3(2) ADP + AfsR phosphoprotein
-
?
additional information AfsK is a Hanks-type protein kinase Streptomyces coelicolor ?
-
?
additional information AfsK, PkaG, and SCD10 perform autophosphorylation Streptomyces coelicolor ?
-
?
additional information AfsK is a Hanks-type protein kinase Streptomyces coelicolor A3(2) ?
-
?
additional information AfsK, PkaG, and SCD10 perform autophosphorylation Streptomyces coelicolor A3(2) ?
-
?

Synonyms

Synonyms Comment Organism
AsfK
-
Streptomyces coelicolor
PkaG
-
Streptomyces coelicolor
SCD10.09
-
Streptomyces coelicolor
serine/threonine kinase
-
Streptomyces coelicolor

Cofactor

Cofactor Comment Organism Structure
ATP
-
Streptomyces coelicolor