Activating Compound | Comment | Organism | Structure |
---|---|---|---|
protein 14-3-3 | a dimeric scaffold protein, protein is absolutely required for connection by simultaneous binding of glycogen synthase kinase-3 beta to tau within a brain microtubule-associated tau phosphorylation complex | Bos taurus |
Cloned (Comment) | Organism |
---|---|
co-expression of glycogen synthase kinase-3 beta, tau, and 14-3-3 in COS-7 cells and in HEK-293 cells | Bos taurus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoskeleton | - |
Bos taurus | 5856 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Bos taurus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [tau-protein] | Bos taurus | substrate of GSK3beta in brain | ADP + O-phospho-[tau-protein] | - |
? | |
additional information | Bos taurus | glycogen synthase kinase-3beta also performs the tau-protein kinase reaction, EC 2.7.11.26, phosphorylating tau protein at serine and threonine residues | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
ATP + a [protein]-(L-serine/L-threonine) = ADP + a [protein]-(L-serine/L-threonine) phosphate | glycogen synthase kinase-3beta also performs the tau-protein kinase reaction, EC 2.7.11.26 | Bos taurus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Bos taurus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [tau-protein] | - |
Bos taurus | ADP + O-phospho-[tau-protein] | - |
? | |
ATP + [tau-protein] | substrate of GSK3beta in brain | Bos taurus | ADP + O-phospho-[tau-protein] | - |
? | |
additional information | glycogen synthase kinase-3beta also performs the tau-protein kinase reaction, EC 2.7.11.26, phosphorylating tau protein at serine and threonine residues | Bos taurus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
glycogen synthase kinase-3beta | - |
Bos taurus |
More | see also EC 2.7.11.26 | Bos taurus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Bos taurus |