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Literature summary for 2.7.11.1 extracted from
- Protamine kinase phosphorylates eukaryotic protein synthesis initiation factor 4E (1992), Biochem. Biophys. Res. Commun., 183, 431-437.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| KCl | eIF-4E as substrate | Bos taurus |  |
| NaCl | eIF-4E | Bos taurus | |
| Protein phosphatase 2A | eIF-4E, 40S ribosomes or protamine as substrate | Bos taurus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Bos taurus | 5829 | - |
| soluble | - |
Bos taurus | - |
- |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | 1 mM (eIF-4E as substrate) | Bos taurus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| kidney | - |
Bos taurus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + eukaryotic protein synthesis initiation factor | i.e. eIF-4E, 1 mol phosphate per mol eIF-4E | Bos taurus | ? | - |
? | |
| ATP + protamine | - |
Bos taurus | ADP + O-phosphoprotamine | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 30 | - |
assay at | Bos taurus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7 | 7.6 | eIF-4E as substrate | Bos taurus |
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Release 2023.1 (January 2023)
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