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Literature summary for 2.7.11.1 extracted from

  • Johnston, A.M.; Naselli, G.; Gonez, L.J.; Martin, R.M.; Harrison, L.C.; DeAizpurua, H.J.
    SPAK, a STE20/SPS1-related kinase that activates the p38 pathway (2000), Oncogene, 19, 4290-4297.
    View publication on PubMed
Search for more literature for 2.7.11.1

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm full-length SPAK is expressed in the cytoplasm in transfected cells Rattus norvegicus 5737
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nucleus in a mutant corresponding to caspase-cleaved SPAK the enzyme is expressed predominantly in the nucleus Rattus norvegicus 5634
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + protein Rattus norvegicus enzyme activates the p38 pathway, SPAK may act as a novel mediator of stress-activated signals ADP + phosphoprotein
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9UEW8
-
-
Mus musculus Q9Z1W9
-
-
Rattus norvegicus O88506
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein autophosphorylation Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
brain preferentially expressed in brain and pancreas Rattus norvegicus
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pancreas preferentially expressed in brain and pancreas Rattus norvegicus
-
pancreatic beta cell line
-
 Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + protein autophosphorylation Rattus norvegicus ADP + phosphoprotein
-
 ?
ATP + protein enzyme activates the p38 pathway, SPAK may act as a novel mediator of stress-activated signals Rattus norvegicus ADP + phosphoprotein
-
 ?

Synonyms

Synonyms Comment Organism
SPAK
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 Rattus norvegicus
STE20/SPS1-related proline-alanine rich protein kinase
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 Rattus norvegicus
STE20/SPS1-related proline-alanine rich protein kinase
-
 Homo sapiens
STE20/SPS1-related proline-alanine rich protein kinase
-
 Mus musculus
STE20/SPS1-related, proline alanine-rich kinase
-
 Rattus norvegicus