Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | Chk2 is rapidly phosphorylated and activated in response to replication blocks and DNA damage, the response to DNA damage occurrs in an ataxia telangiectasia mutated ATM-dependent manner | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | in response to DNA damage and DNA replicational stress, Chk1 and Chk2 may phosphorylate Cdc25C to prevent entry into mitosis | ? | - |
? | |
additional information | Mus musculus | in response to DNA damage and DNA replicational stress, Chk1 and Chk2 may phosphorylate Cdc25C to prevent entry into mitosis | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O96017 | - |
- |
Mus musculus | Q9Z265 | - |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | Chk2 is rapidly phosphorylated and activated in response to replication blocks and DNA damage | Homo sapiens |
phosphoprotein | Chk2 is rapidly phosphorylated and activated in response to replication blocks and DNA damage | Mus musculus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + Cdc25C | Chk2 phosphorylated Cdc25C on Ser216 | Homo sapiens | ADP + ? | - |
? | |
ATP + Cdc25C | phosphorylated Cdc25C on Ser216 | Mus musculus | ADP + phosphorylated Cdc25C | - |
? | |
additional information | in response to DNA damage and DNA replicational stress, Chk1 and Chk2 may phosphorylate Cdc25C to prevent entry into mitosis | Homo sapiens | ? | - |
? | |
additional information | in response to DNA damage and DNA replicational stress, Chk1 and Chk2 may phosphorylate Cdc25C to prevent entry into mitosis | Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
serine/threonine-protein kinase Chk2 | - |
Homo sapiens |
serine/threonine-protein kinase Chk2 | - |
Mus musculus |