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Literature summary for 2.7.11.1 extracted from

  • Park, J.; Leong, M.L.; Buse, P.; Maiyar, A.C.; Firestone, G.L.; Hemmings, B.A.
    Serum and glucocorticoid-inducible kinase (SGK) is a target of the PI 3-kinase-stimulated signaling pathway (1999), EMBO J., 18, 3024-3033.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.1

Activating Compound

Activating Compound Comment Organism Structure
additional information transcriptionally regulated by serum and glucocorticoids in mammary epithelial cells Rattus norvegicus

Protein Variants

Protein Variants Comment Organism
S442X mutation of putative phosphorylation sites at Thr256 and Ser422 inhibited SGK activation Rattus norvegicus
T256X mutation of putative phosphorylation sites at Thr256 and Ser422 inhibited SGK activation Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
additional information treatment of rat mammary tumor cells with serum causes hyperphosphorylation of endogenous SGK, and a promoted translocation to the nucleus Rattus norvegicus
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus the enzyme is transcriptionally regulated by serum and glucocorticoids in mammary epithelial cells, hormone-regulated protein kinase gene with a functionally defined p53 promoter recognition element ?
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 ?
additional information Rattus norvegicus enzyme is induced during ovarian cell differentiation ?
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 ?
additional information Rattus norvegicus SGK is a component of the phosphoinositide 3 (PI 3)-kinase signaling pathway ?
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 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus Q06226
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Source Tissue

Source Tissue Comment Organism Textmining
embryo embryo kidney 293 cells Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme is transcriptionally regulated by serum and glucocorticoids in mammary epithelial cells, hormone-regulated protein kinase gene with a functionally defined p53 promoter recognition element Rattus norvegicus ?
-
 ?
additional information enzyme is induced during ovarian cell differentiation Rattus norvegicus ?
-
 ?
additional information SGK is a component of the phosphoinositide 3 (PI 3)-kinase signaling pathway Rattus norvegicus ?
-
 ?

Synonyms

Synonyms Comment Organism
serine/threonine-protein kinase Sgk
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 Rattus norvegicus
SGK
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 Rattus norvegicus