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Literature summary for 2.7.10.2 extracted from

  • Kuka, M.; Baronio, R.; Valentini, S.; Monaci, E.; Muzzi, A.; Aprea, S.; De Gregorio, E.; DOro, U.
    Src kinases are required for a balanced production of IL-12/IL-23 in human dendritic cells activated by Toll-like receptor agonists (2010), PLoS ONE, 5, e11491.
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
dendritic cell
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 Homo sapiens
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General Information

General Information Comment Organism
physiological function Src family kinases are important for a balanced production of inflammatory cytokines by human monocyte-derived dendritic cells upon stimulation of toll-like receptors TLR3 and TLR8 with their respective agonists. Disruption of this equilibrium through pharmacological inhibition of Src kinases alters the dendritic cell maturation pattern. While expression of interleukin IL-12 and other inflammatory cytokines depends on Src kinases, the induction of IL-23 and co-stimulatory molecules does not. Dendritic cells treated with Src inhibitors are not compromised in their ability to induce CD4 T cell proliferation and to promote the T helper cell Th17 subset survival but are less efficient in inducing T helper cell Th1 differentiation Homo sapiens