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Literature summary for 2.7.10.2 extracted from
- Src family tyrosine kinases activate thrombin-induced non-capacitative cation entry in human platelets (2010), Platelets, 21, 445-450.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 4-amino-5-(4-chlorophenyl)-7-(tert-butyl)pyrazolo[3,4-d]pyrimidine | application completely abolishes thrombin-induced non-capacitative cation entry into platelets, a Ca2+ entry pathway that is independent of Ca2+ store depletion. Src family tyrosine kinase activation is a required step in non-capacitative cation entry activation | Homo sapiens |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| blood platelet | - |
Homo sapiens | - |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | Src family tyrosine kinase activation is a required step in non-capacitative cation entry activation. Application of specific inhibitor 4-amino-5-(4-chlorophenyl)-7-(tert-butyl)pyrazolo[3,4-d]pyrimidine completely abolishes thrombin-induced non-capacitative cation entry into platelets, a Ca2+ entry pathway that is independent of Ca2+ store depletion | Homo sapiens |
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