Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [protein kinase C zeta]-L-tyrosine | Rattus norvegicus | - |
ADP + [protein kinase C zeta]-L-tyrosine phosphate | Src kinase plays an important role in angiotensin II-elicited protein kinase C zeta activation and the subsequent downstream signaling including ERK1/2 activation and vascular smooth muscle cell proliferation | ? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | Q9WUD9 | SRC | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
muscle | vascular smooth muscle cells | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [protein kinase C zeta]-L-tyrosine | - |
Rattus norvegicus | ADP + [protein kinase C zeta]-L-tyrosine phosphate | Src kinase plays an important role in angiotensin II-elicited protein kinase C zeta activation and the subsequent downstream signaling including ERK1/2 activation and vascular smooth muscle cell proliferation | ? |
Synonyms | Comment | Organism |
---|---|---|
Src | - |
Rattus norvegicus |
General Information | Comment | Organism |
---|---|---|
physiological function | Src kinase plays an important role in angiotensin II-elicited protein kinase C zeta activation and the subsequent downstream signaling including ERK1/2 activation and vascular smooth muscle cell proliferation. Angiotensin II induces rapid activation of protein kinase C zeta, which is associated with its phosphorylation and nuclear translocation. angiotensin II not only induces activation by Src, but also promotes the physical association between Src and protein kinase C zeta, which is abolished by Src inhibition with inhibitor 4-amino-5-(4-chlorophenyl)-7-(tert-butyl)pyrazolo[3,4-d]pyrimidine. Src inhibition also abrogates angiotensin II-stimulated protein kinase C zeta activation, ERK1/2 phosphorylation and vascular smooth muscle cell proliferation | Rattus norvegicus |