Application | Comment | Organism |
---|---|---|
medicine | in isoform Btk-deficient patients with X-linked agammaglobulinemia, reduced toll-like receptor TLR3-triggered activation of human natural killer cells is observed, as evidenced by the reduced IFN-gamma, CD69, and CD107a expression and cytotoxic activity | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q06187 | Btk | - |
Mus musculus | P35991 | Btk | - |
Synonyms | Comment | Organism |
---|---|---|
Bruton tyrosine kinase | - |
Mus musculus |
Bruton tyrosine kinase | - |
Homo sapiens |
Btk | - |
Mus musculus |
Btk | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Mus musculus | isoform Btk expression is up-regulated during maturation and activation of mouse natural killer cells | up |
General Information | Comment | Organism |
---|---|---|
physiological function | murine Btk-/- natural killer cells have decreased innate immune responses to the toll-like receptor TLR3 ligand, with reduced expressions of IFN-gamma, perforin, and granzyme-B and decreased cytotoxic activity. Isoform Btk promotes TLR3-triggered natural killer cell activation mainly by activating the NF-kappaB pathway. Poly(I:C)-induced natural killer cell-mediated acute hepatitis is attenuated in Btk-/- mice or the mice with in vivo administration of Btk inhibitor. Correspondingly, liver damage is aggravated in Btk-/- mice after the adoptive transfer of Btk-/- natural killer cells | Mus musculus |