Literature summary for 2.7.10.2 extracted from

Bao, Y.; Zheng, J.; Han, C.; Jin, J.; Han, H.; Liu, Y.; Lau, Y.; Tu, W.; Cao, X.
Tyrosine kinase Btk is required for NK cell activation (2012), J. Biol. Chem., 287, 23769-23778.

Search for more literature for 2.7.10.2

Application

Application	Comment	Organism
medicine	in isoform Btk-deficient patients with X-linked agammaglobulinemia, reduced toll-like receptor TLR3-triggered activation of human natural killer cells is observed, as evidenced by the reduced IFN-gamma, CD69, and CD107a expression and cytotoxic activity	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q06187	Btk	-
Mus musculus	P35991	Btk	-

Synonyms

Synonyms	Comment	Organism
Bruton tyrosine kinase	-	Mus musculus
Bruton tyrosine kinase	-	Homo sapiens
Btk	-	Mus musculus
Btk	-	Homo sapiens

Expression

Organism	Comment	Expression
Mus musculus	isoform Btk expression is up-regulated during maturation and activation of mouse natural killer cells	up

General Information

General Information	Comment	Organism
physiological function	murine Btk-/- natural killer cells have decreased innate immune responses to the toll-like receptor TLR3 ligand, with reduced expressions of IFN-gamma, perforin, and granzyme-B and decreased cytotoxic activity. Isoform Btk promotes TLR3-triggered natural killer cell activation mainly by activating the NF-kappaB pathway. Poly(I:C)-induced natural killer cell-mediated acute hepatitis is attenuated in Btk-/- mice or the mice with in vivo administration of Btk inhibitor. Correspondingly, liver damage is aggravated in Btk-/- mice after the adoptive transfer of Btk-/- natural killer cells	Mus musculus

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Release 2023.1 (January 2023)