Literature summary for 2.7.10.2 extracted from

Deng, Y.; Couch, B.; Koleske, A.; Turk, B.
A Peptide photoaffinity probe specific for the active conformation of the Abl tyrosine kinase (2012), ChemBioChem, 13, 2510-2512.

Search for more literature for 2.7.10.2

Application

Application	Comment	Organism
analysis	peptide photoaffinity probe GAPEVIYA-4-azidophenylalanyl-PGAKKKGK(biotin) based on consensus substrate GAPEVIYATPGAKKK. Incubation of purified recombinant isoform Abl results in covalent incorporation of biotin. The label crosslinks to Abl specifically through binding to the active site cleft into the kinase. Abl activity is enhanced by phosphorylation at multiple sites, the extent of labeling increases with increasing catalytic activity	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + GAPEVIYATPGAKKK	consensus substrate	Homo sapiens	ADP + GAPEVI-phosphotyrosinyl-ATPGAKKK	-	?

Synonyms

Synonyms	Comment	Organism
Abl tyrosine kinase	-	Homo sapiens

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Release 2023.1 (January 2023)