Activating Compound | Comment | Organism | Structure |
---|---|---|---|
pervanadate | activation of isoform Fer by reactive oxygen species causes increased phosphorylation of RhoGDIalpha, regulator of the small GTPase Rac, and pervanadate treatment further augmented this | Homo sapiens | |
reactive oxygen species | activation of isoform Fer by reactive oxygen species causes increased phosphorylation of RhoGDIalpha, regulator of the small GTPase Rac, and pervanadate treatment further augmented this | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P16591 | FER | - |
Synonyms | Comment | Organism |
---|---|---|
FER tyrosine kinase | - |
Homo sapiens |
TYK3 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | non-receptor tyrosine kinase Fer is able to phosphorylate RhoGDIalpha, regulator of the small GTPase Rac, and form a direct protein complex with it. This interaction is mediated by the C-terminal end of RhoGDIalpha. Tyrosine phosphorylation of RhoGDIalpha by Fer prevents subsequent binding of Rac to RhoGDIalpha, but once a RhoGDIalpha-Rac complex is formed, the Fer kinase is not able to cause Rac release through tyrosine phosphorylation of preformed RhoGDIalpha-Rac complexes | Homo sapiens |