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Literature summary for 2.7.10.2 extracted from

  • Vainchenker, W.; Dusa, A.; Constantinescu, S.N.
    JAKs in pathology: role of Janus kinases in hematopoietic malignancies and immunodeficiencies (2008), Semin. Cell Dev. Biol., 19, 385-393.
    View publication on PubMed
Search for more literature for 2.7.10.2

Protein Variants

Protein Variants Comment Organism
additional information mutations and translocations in the JAK genes leading to constitutively active JAK proteins are associated with a variety of hematopoietic malignancies, including the myeloproliferative disorders (JAK2), acute lymphoblastic leukemia (JAK2), acute myeloid leukemia (JAK2, JAK1), acute megakaryoblastic leukemia (JAK2, JAK3) and T-cell precursor acute lymphoblastic leukemia (JAK1), loss-of-function mutations of JAK3 and TYK2 lead to immunodeficiency Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + a [protein]-L-tyrosine Homo sapiens
-
 ADP + a [protein]-L-tyrosine phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + a [protein]-L-tyrosine
-
 Homo sapiens ADP + a [protein]-L-tyrosine phosphate
-
 ?

Synonyms

Synonyms Comment Organism
Jak1
-
 Homo sapiens
JAK2
-
 Homo sapiens
Jak3
-
 Homo sapiens
Janus kinase
-
 Homo sapiens
non-receptor protein tyrosine kinase
-
 Homo sapiens
PTK
-
 Homo sapiens
Tyk2
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function crucial for cytokine receptor signaling in blood formation and immune responses Homo sapiens