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Literature summary for 2.7.10.2 extracted from

  • Monroe, R.K.; Halvorsen, S.W.
    Environmental toxicants inhibit neuronal Jak tyrosine kinase by mitochondrial disruption (2009), Neurotoxicology, 30, 589-598.
    View publication on PubMed
Search for more literature for 2.7.10.2

Inhibitors

Inhibitors Comment Organism Structure
additional information exposure of BE(2)-C cells to the heavy metals Cd2+ and Hg2+ and to rotenone inhibits interleukin-6, interferon-gamma and ciliary neurotrophic factor-mediated Jak/STAT signaling, reduces Jak1 and Jak2 autophosphorylation and induces Jak tyrosine nitration by mitochondrial disruption. Identical exposure of HepG2 hepatoma cells produces no inhibition of these cytokine responses. Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Hep-G2 cell
-
 Homo sapiens
-
neuroblastoma cell
-
 Homo sapiens
-
SK-N-BE(2)C cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + signal transducer and activator of transcription
-
 Homo sapiens ADP + phospho-L-tyrosinyl-signal transducer and activator of transcription
-
 ?

Synonyms

Synonyms Comment Organism
Jak tyrosine kinase
-
 Homo sapiens
Jak1
-
 Homo sapiens
JAK2
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens