Inhibitors | Comment | Organism | Structure |
---|---|---|---|
AG490 | - |
Homo sapiens | |
INCB20 | potently inhibits all members of the JAK family with a 100-1000fold selectivity for JAKs over more than 70 other kinases, potent and specific Pan-JAK inhibitor | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
INA-6 cell | - |
Homo sapiens | - |
myeloma cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + EQEDEPEGDYFEWLE | - |
Homo sapiens | ADP + EQEDEPEGDpYFEWLE | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Jak1 | - |
Homo sapiens |
JAK2 | - |
Homo sapiens |
Jak3 | - |
Homo sapiens |
Janus kinase | - |
Homo sapiens |
Tyk2 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0000003 | - |
TYK2, in 50 mM, Tris-HCl (pH 7.8), 100 mM NaCl, 5 mM dithiothreitol, and 0.1 mg/ml bovine serum albumin, at 25°C | Homo sapiens | INCB20 | |
0.0000005 | - |
JAK2, in 50 mM, Tris-HCl (pH 7.8), 100 mM NaCl, 5 mM dithiothreitol, and 0.1 mg/ml bovine serum albumin, at 25°C | Homo sapiens | INCB20 | |
0.0000005 | - |
JAK3, in 50 mM, Tris-HCl (pH 7.8), 100 mM NaCl, 5 mM dithiothreitol, and 0.1 mg/ml bovine serum albumin, at 25°C | Homo sapiens | INCB20 | |
0.0000009 | - |
JAK1, in 50 mM, Tris-HCl (pH 7.8), 100 mM NaCl, 5 mM dithiothreitol, and 0.1 mg/ml bovine serum albumin, at 25°C | Homo sapiens | INCB20 | |
0.0102 | - |
JAK1, in 50 mM, Tris-HCl (pH 7.8), 100 mM NaCl, 5 mM dithiothreitol, and 0.1 mg/ml bovine serum albumin, at 25°C | Homo sapiens | AG490 | |
0.0112 | - |
JAK2, in 50 mM, Tris-HCl (pH 7.8), 100 mM NaCl, 5 mM dithiothreitol, and 0.1 mg/ml bovine serum albumin, at 25°C | Homo sapiens | AG490 | |
0.0154 | - |
JAK3, in 50 mM, Tris-HCl (pH 7.8), 100 mM NaCl, 5 mM dithiothreitol, and 0.1 mg/ml bovine serum albumin, at 25°C | Homo sapiens | AG490 |