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Literature summary for 2.7.10.2 extracted from
- The tyrosine kinase Pyk2 mediates lipopolysaccharide-induced IL-8 expression in human endothelial cells (2008), J. Immunol., 180, 5636-5644.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| lipopolysaccharide | LPS | Homo sapiens |  |
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | Pyk2 may represent a novel target for the development of innovative therapeutic strategies against inflammatory conditions | Homo sapiens |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| the kinase-inactive Pyk2 mutant is cloned using an AAV vector | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| Pyk2K457A | Pyk2MT, dominant negative Pyk2 mutant, inactive | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Pyk2-specific siRNA | - |
Homo sapiens | |
| tyrphostin A9 | - |
Homo sapiens | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 117000 | - |
determined by SDS-PAGE and Western Blot analysis | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + [protein]-L-tyrosine | Homo sapiens | - |
ADP + [protein]-L-tyrosine phosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| endothelial cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + poly(Glu-Tyr) | substrate used in the activity assay | Homo sapiens | ? + ADP | - |
? | |
| ATP + [protein]-L-tyrosine | - |
Homo sapiens | ADP + [protein]-L-tyrosine phosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Pyk2 | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 23 | - |
immune complex kinase assay | Homo sapiens |
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Release 2023.1 (January 2023)
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