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Literature summary for 2.7.10.2 extracted from

  • Tsuda, M.; Tozaki-Saitoh, H.; Masuda, T.; Toyomitsu, E.; Tezuka, T.; Yamamoto, T.; Inoue, K.
    Lyn tyrosine kinase is required for P2X(4) receptor upregulation and neuropathic pain after peripheral nerve injury (2008), Glia, 56, 50-58.
    View publication on PubMed
Search for more literature for 2.7.10.2

Activating Compound

Activating Compound Comment Organism Structure
additional information nerve injury induces the activation of Src family kinases, Lyn is the predominant kinase Mus musculus
additional information nerve injury induces the activation of Src family kinases, Lyn is the predominant kinase Rattus norvegicus

Application

Application Comment Organism
medicine Lyn is a key kinase in the molecular machineries mediating the P2X4R upregulation in microglia, and thereby, in neuropathic pain Mus musculus
medicine Lyn is a key kinase in the molecular machineries mediating the P2X4R upregulation in microglia, and thereby, in neuropathic pain Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
53000
-
 alternative splicing variant, identified by SDS-PAGE and Western blot analysis Mus musculus
53000
-
 alternative splicing variant, identified by SDS-PAGE and Western blot analysis Rattus norvegicus
56000
-
 identified by SDS-PAGE and Western blot analysis Mus musculus
56000
-
 identified by SDS-PAGE and Western blot analysis Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [protein]-L-tyrosine Mus musculus
-
 ADP + [protein]-L-tyrosine phosphate
-
 ?
ATP + [protein]-L-tyrosine Rattus norvegicus
-
 ADP + [protein]-L-tyrosine phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus P25911
-
-
Rattus norvegicus Q07014 male Wistar rats
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein full activation requires autophosphorylation at a tyrosine residue located in the kinase domain Mus musculus
phosphoprotein full activation requires autophosphorylation at a tyrosine residue located in the kinase domain Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Mus musculus
-
brain
-
 Rattus norvegicus
-
microglia spinal microglia Mus musculus
-
microglia spinal microglia Rattus norvegicus
-
neuron
-
 Mus musculus
-
neuron
-
 Rattus norvegicus
-
spinal nerve
-
 Mus musculus
-
spinal nerve
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [protein]-L-tyrosine
-
 Mus musculus ADP + [protein]-L-tyrosine phosphate
-
 ?
ATP + [protein]-L-tyrosine
-
 Rattus norvegicus ADP + [protein]-L-tyrosine phosphate
-
 ?

Synonyms

Synonyms Comment Organism
Lyn tyrosine kinase
-
 Mus musculus
Lyn tyrosine kinase
-
 Rattus norvegicus