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Literature summary for 2.7.10.2 extracted from
- The tyrosine kinase Abl is required for Src-transforming activity in mouse fibroblasts and human breast cancer cells (2007), Oncogene, 26, 7313-7323.
Application
| Application | Comment | Organism |
|---|---|---|
| pharmacology | targeting these Abl-dependent signalling cascades may be of therapeutic value in breast cancers where Src-like function is important | Homo sapiens |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression of Abl in NIH 3T3 cells and in HEK-293 cells | Mus musculus |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | downregulation of Abl expression by siRNA expression in NIH 3T3 cells reduces Src-mT-induced foci | Mus musculus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| imatinib | - |
Homo sapiens |  |
| imatinib | - |
Mus musculus | |
| SU6656 | - |
Homo sapiens | |
| SU6656 | - |
Mus musculus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | Src | Mus musculus | 5737 | - |
| cytoplasm | Src | Homo sapiens | 5737 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | - |
Mus musculus | |
| Mg2+ | - |
Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + Abl | Homo sapiens | Abl is an important substrate for Src signalling in normal cells | ADP + phospho-L-tyrosinyl-Abl | - |
? | |
| ATP + Abl | Mus musculus | Abl is an important substrate for Src signalling in normal cells, Abl is also required for Src-induced transformation of mouse fibroblasts, overview | ADP + phospho-L-tyrosinyl-Abl | - |
? | |
| additional information | Mus musculus | Src and Abl regulation, overview, cytoplasmic tyrosine kinase Src is involved in signal transduction induced by growth factors and integrins, Src also shows oncogenic activity when it is deregulated, Abl mediates Src-induced extracellular regulated kinase 5, ERK5, activation to drive cell transformation | ? | - |
? | |
| additional information | Homo sapiens | Src and Abl regulation, overview, cytoplasmic tyrosine kinase Src is involved in signal transduction induced by growth factors and integrins, Src also shows oncogenic activity when it is deregulated, Abl mediates Src-induced extracellular regulated kinase 5, ERK5, activation to drive cell transformation, Abl/Rac and Abl/ERK5 pathways also operate in human MCF7 and BT549 breast cancer cells, where neoplastic transformation depends on Src-like activities, overview | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| breast cancer cell | - |
Homo sapiens | - |
| BT-549 cell | - |
Homo sapiens | - |
| fibroblast | - |
Mus musculus | - |
| MCF-7 cell | - |
Homo sapiens | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Mus musculus |
| additional information | - |
- |
Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + Abl | Abl is an important substrate for Src signalling in normal cells | Homo sapiens | ADP + phospho-L-tyrosinyl-Abl | - |
? | |
| ATP + Abl | Abl is an important substrate for Src signalling in normal cells, Abl is also required for Src-induced transformation of mouse fibroblasts, overview | Mus musculus | ADP + phospho-L-tyrosinyl-Abl | - |
? | |
| ATP + Abl | Abl is a substrate of Src | Homo sapiens | ADP + phospho-L-tyrosinyl-Abl | - |
? | |
| ATP + Abl | Abl is a substrate of Src, phosphorylation on Tyr245 and Tyr412 | Mus musculus | ADP + phospho-L-tyrosinyl-Abl | - |
? | |
| additional information | Src and Abl regulation, overview, cytoplasmic tyrosine kinase Src is involved in signal transduction induced by growth factors and integrins, Src also shows oncogenic activity when it is deregulated, Abl mediates Src-induced extracellular regulated kinase 5, ERK5, activation to drive cell transformation | Mus musculus | ? | - |
? | |
| additional information | Src and Abl regulation, overview, cytoplasmic tyrosine kinase Src is involved in signal transduction induced by growth factors and integrins, Src also shows oncogenic activity when it is deregulated, Abl mediates Src-induced extracellular regulated kinase 5, ERK5, activation to drive cell transformation, Abl/Rac and Abl/ERK5 pathways also operate in human MCF7 and BT549 breast cancer cells, where neoplastic transformation depends on Src-like activities, overview | Homo sapiens | ? | - |
? | |
| additional information | Abl does not mediate tyrosine phosphorylation of Stat3 and Shc, two important regulators of Src oncogenic activity | Mus musculus | ? | - |
? | |
| additional information | Abl does not mediate tyrosine phosphorylation of Stat3 and Shc, two important regulators of Src oncogenic activity | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Abl | - |
Mus musculus |
| Abl | - |
Homo sapiens |
| Src | - |
Mus musculus |
| Src | - |
Homo sapiens |
| tyrosine kinase Abl | - |
Mus musculus |
| tyrosine kinase Abl | - |
Homo sapiens |
| tyrosine kinase Src | - |
Mus musculus |
| tyrosine kinase Src | - |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Mus musculus | |
| ATP | - |
Homo sapiens | |
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