Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | Akt is activated by phosphorylation at Ser473 and at Thr308 | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
curcumin | downregulates and inhibits tyrosine kinase Syk, which leads to inhibition of Akt, in lymphoma cells, curcumin causes growth inhibition of B lymphoma, mechanism, overview | Homo sapiens | |
curcumin | downregulates and inhibits tyrosine kinase Syk, which leads to inhibition of Akt, in lymphoma cells, curcumin causes growth inhibition of B lymphoma, mechanism, overview | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + Bad protein | Mus musculus | substrate of Akt | ADP + phosphotyrosinyl Bad protein | - |
? | |
ATP + Bad protein | Homo sapiens | substrate of Akt | ADP + phosphotyrosinyl Bad protein | - |
? | |
ATP + glycogen synthase kinase 3beta | Mus musculus | substrate of Akt | ADP + phosphotyrosinyl glycogen synthase kinase 3beta | - |
? | |
ATP + glycogen synthase kinase 3beta | Homo sapiens | substrate of Akt | ADP + phosphotyrosinyl glycogen synthase kinase 3beta | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | Akt is activated by phosphorylation at Ser473 and at Thr308 | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
B-cell lymphoma cell | Akt and Syk, the latter is constitutively activated in primary tumor cells | Homo sapiens | - |
B-cell lymphoma cell | Ly-10 DLBCL cells or WEHI-231 cells, Akt and Syk, the latter is constitutively activated in primary tumor cells | Mus musculus | - |
spleen | Syk | Mus musculus | - |
spleen | Syk | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + Bad protein | substrate of Akt | Mus musculus | ADP + phosphotyrosinyl Bad protein | - |
? | |
ATP + Bad protein | substrate of Akt | Homo sapiens | ADP + phosphotyrosinyl Bad protein | - |
? | |
ATP + glycogen synthase kinase 3beta | substrate of Akt | Mus musculus | ADP + phosphotyrosinyl glycogen synthase kinase 3beta | - |
? | |
ATP + glycogen synthase kinase 3beta | substrate of Akt | Homo sapiens | ADP + phosphotyrosinyl glycogen synthase kinase 3beta | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AKT | - |
Mus musculus |
AKT | - |
Homo sapiens |
Syk | - |
Mus musculus |
Syk | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
22 | - |
assay at room temperature | Mus musculus |
22 | - |
assay at room temperature | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Mus musculus | |
ATP | - |
Homo sapiens |