Activating Compound | Comment | Organism | Structure |
---|---|---|---|
epidermal growth factor receptor | the Abl nonreceptor tyrosine kinase is activated by ligand-stimulated EGFR | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
co-expression of EGFR and Abl in COS-7 cell surface, expression in HEK-293 cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
K290M | a kinase-inactive Abl mutant | Homo sapiens |
additional information | Abl-PP harbors mutations in prolines 242 and 249 in theSH2kinase linker domain, which are mutated to glutamic acid, rendering Abl in a constitutively active state | Homo sapiens |
P131L | a SH3-domain mutant with increased activity compared to wild-type Abl | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + epidermal growth factor receptor | Homo sapiens | the activated Abl tyrosine kinase negaively regulates endocytosis of the epidermal growth factor, e.g. in NR6 cells, overview, Abl allows the ligand-activated EGFR to escape Cbl-dependent down-regulation by inhibiting the accumulation of Cbl at the plasma membrane in response to epidermal growth factor stimulation and disrupting the formation of the EGFR-Cbl complex without affecting Cbl protein stability | ADP + phospho-L-tyrosinyl-epidermal growth factor receptor | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + epidermal growth factor receptor | the activated Abl tyrosine kinase negaively regulates endocytosis of the epidermal growth factor, e.g. in NR6 cells, overview, Abl allows the ligand-activated EGFR to escape Cbl-dependent down-regulation by inhibiting the accumulation of Cbl at the plasma membrane in response to epidermal growth factor stimulation and disrupting the formation of the EGFR-Cbl complex without affecting Cbl protein stability | Homo sapiens | ADP + phospho-L-tyrosinyl-epidermal growth factor receptor | - |
? | |
ATP + epidermal growth factor receptor | activated Abl phosphorylates the EGFR primarily on Tyr1173, no activity with the Tyr1173 mutant substrate | Homo sapiens | ADP + phospho-L-tyrosinyl-epidermal growth factor receptor | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Abl | - |
Homo sapiens |
Abl nonreceptor tyrosine kinase | - |
Homo sapiens |
Abl tyrosine kinase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |