Cloned (Comment) | Organism |
---|---|
expression of wild-type and mutant human brain-type Fyns in a two-hybrid system in yeast cells with human or mouse TCGAP, wild-type and mutant, overview, expression of wild-type and mutant enzymes in HEK-293T cells and in PC12 cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
K299M | inactive mutant, interacts with TCGAP, coexpression of FynY531F, SH2-defective R176K, and SH3-defective P134K mutants, but not K299M, with TCGAP enhance tyrosine phosphorylation of TCGAP | Homo sapiens |
P134L | an SH3-defective mutant, no interaction with TCGAP, coexpression of FynY531F, SH2-defective R176K, and SH3-defective P134K mutants, but not K299M, with TCGAP enhance tyrosine phosphorylation of TCGAP | Homo sapiens |
R176K | an SH2-defective mutant, interacts with TCGAP, coexpression of FynY531F, SH2-defective R176K, and SH3-defective P134K mutants, but not K299M, with TCGAP enhance tyrosine phosphorylation of TCGAP | Homo sapiens |
Y531F | coexpression of FynY531F, SH2-defective R176K, and SH3-defective P134K mutants, but not K299M, with TCGAP enhance tyrosine phosphorylation of TCGAP | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + Tc10/Cdc42 GTPase-activating protein | Homo sapiens | physical and functional interaction of Fyn with the brain-enriched Rho GTPase-activating protein Tc10/Cdc42 GTPase-activating protein, i.e. TCGAP, TCGAP is involved in Fyn-mediated regulation of axon and dendrite outgrowth | ADP + phospho-L-tyrosinyl-Tc10/Cdc42 GTPase-activating protein | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + Tc10/Cdc42 GTPase-activating protein | physical and functional interaction of Fyn with the brain-enriched Rho GTPase-activating protein Tc10/Cdc42 GTPase-activating protein, i.e. TCGAP, TCGAP is involved in Fyn-mediated regulation of axon and dendrite outgrowth | Homo sapiens | ADP + phospho-L-tyrosinyl-Tc10/Cdc42 GTPase-activating protein | - |
? | |
ATP + Tc10/Cdc42 GTPase-activating protein | physical and functional interaction of Fyn with the brain-enriched Rho GTPase-activating protein Tc10/Cdc42 GTPase-activating protein, i.e. TCGAP, phosphorylation mainly at Tyr406, no activity with TCGAP Y406F mutant, recombinant substrate from mouse and human, overview | Homo sapiens | ADP + phospho-L-tyrosinyl-Tc10/Cdc42 GTPase-activating protein | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Fyn | - |
Homo sapiens |
Fyn tyrosine kinase | - |
Homo sapiens |
More | the enzyme is a member of the Src family of tyrosine kinases | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |