Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.10.2 extracted from

  • Liu, H.; Nakazawa, T.; Tezuka, T.; Yamamoto, T.
    Physical and functional interaction of Fyn tyrosine kinase with a brain-enriched Rho GTPase-activating protein TCGAP (2006), J. Biol. Chem., 281, 23611-23619.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression of wild-type and mutant human brain-type Fyns in a two-hybrid system in yeast cells with human or mouse TCGAP, wild-type and mutant, overview, expression of wild-type and mutant enzymes in HEK-293T cells and in PC12 cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
K299M inactive mutant, interacts with TCGAP, coexpression of FynY531F, SH2-defective R176K, and SH3-defective P134K mutants, but not K299M, with TCGAP enhance tyrosine phosphorylation of TCGAP Homo sapiens
P134L an SH3-defective mutant, no interaction with TCGAP, coexpression of FynY531F, SH2-defective R176K, and SH3-defective P134K mutants, but not K299M, with TCGAP enhance tyrosine phosphorylation of TCGAP Homo sapiens
R176K an SH2-defective mutant, interacts with TCGAP, coexpression of FynY531F, SH2-defective R176K, and SH3-defective P134K mutants, but not K299M, with TCGAP enhance tyrosine phosphorylation of TCGAP Homo sapiens
Y531F coexpression of FynY531F, SH2-defective R176K, and SH3-defective P134K mutants, but not K299M, with TCGAP enhance tyrosine phosphorylation of TCGAP Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + Tc10/Cdc42 GTPase-activating protein Homo sapiens physical and functional interaction of Fyn with the brain-enriched Rho GTPase-activating protein Tc10/Cdc42 GTPase-activating protein, i.e. TCGAP, TCGAP is involved in Fyn-mediated regulation of axon and dendrite outgrowth ADP + phospho-L-tyrosinyl-Tc10/Cdc42 GTPase-activating protein
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + Tc10/Cdc42 GTPase-activating protein physical and functional interaction of Fyn with the brain-enriched Rho GTPase-activating protein Tc10/Cdc42 GTPase-activating protein, i.e. TCGAP, TCGAP is involved in Fyn-mediated regulation of axon and dendrite outgrowth Homo sapiens ADP + phospho-L-tyrosinyl-Tc10/Cdc42 GTPase-activating protein
-
?
ATP + Tc10/Cdc42 GTPase-activating protein physical and functional interaction of Fyn with the brain-enriched Rho GTPase-activating protein Tc10/Cdc42 GTPase-activating protein, i.e. TCGAP, phosphorylation mainly at Tyr406, no activity with TCGAP Y406F mutant, recombinant substrate from mouse and human, overview Homo sapiens ADP + phospho-L-tyrosinyl-Tc10/Cdc42 GTPase-activating protein
-
?

Synonyms

Synonyms Comment Organism
Fyn
-
Homo sapiens
Fyn tyrosine kinase
-
Homo sapiens
More the enzyme is a member of the Src family of tyrosine kinases Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
Homo sapiens