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Literature summary for 2.7.10.2 extracted from

  • Matsui, A.; Okigaki, M.; Amano, K.; Adachi, Y.; Jin, D.; Takai, S.; Yamashita, T.; Kawashima, S.; Kurihara, T.; Miyazaki, M.; Tateishi, K.; Matsunaga, S.; Katsume, A.; Honshou, S.; Takahashi, T.; Matoba, S.; Kusaba, T.; Tatsumi, T.; Matsubara, H.
    Central role of calcium-dependent tyrosine kinase PYK2 in endothelial nitric oxide synthase-mediated angiogenic response and vascular function (2007), Circulation, 116, 1041-1051.
    View publication on PubMed
Search for more literature for 2.7.10.2

Activating Compound

Activating Compound Comment Organism Structure
additional information PYK2 is phosphorylated for activation involving the vascular endothelial growth factor, overview Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information PYK2-deficient phenotype with reduced vasodilatation, response to NO, and neovessel formation, detailed overview Mus musculus

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ dependent on, PYK2 is involved in Ca2+ mobilization in muscle cells Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + Akt tyrosine kinase Mus musculus tyrosine kinase Akt is phosphorylated by PYK2 for activation of the Akt signaling pathway, overview ADP + phosphotyrosinyl-Akt
-
 ?
additional information Mus musculus PYK2 is involved in vascular endothelial growth factor-induced activities, such as cell migration, blood vessel formation, Pyk2 forms complexes with Src tyrosine kinase for activation of the Akt tyrosine kinase pathway, PYK2 is required in receptor- and ischemia-activated signaling events leading to endothelial NO synthase phosphorylation and modulation of endothelial NO synthase-mediated vasoactive function and angiogenic response, PYK2 is involved in Ca2+ mobilization in muscle cells, overview ?
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 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
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-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein PYK2 is phosphorylated for activation involving the vascular endothelial growth factor, while tyrosine kinase Akt is phosphorylated by PYK2 for activation of the Akt signaling pathway overview Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
aorta endothelial cells, PYK2 Mus musculus
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endothelial cell aortic, PYK2, von Willebrand factor-positive cells Mus musculus
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skeletal muscle Akt Mus musculus
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vascular smooth muscle cell PYK2 Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + Akt tyrosine kinase
-
 Mus musculus ADP + phosphotyrosinyl-Akt
-
 ?
ATP + Akt tyrosine kinase tyrosine kinase Akt is phosphorylated by PYK2 for activation of the Akt signaling pathway, overview Mus musculus ADP + phosphotyrosinyl-Akt
-
 ?
additional information PYK2 is involved in vascular endothelial growth factor-induced activities, such as cell migration, blood vessel formation, Pyk2 forms complexes with Src tyrosine kinase for activation of the Akt tyrosine kinase pathway, PYK2 is required in receptor- and ischemia-activated signaling events leading to endothelial NO synthase phosphorylation and modulation of endothelial NO synthase-mediated vasoactive function and angiogenic response, PYK2 is involved in Ca2+ mobilization in muscle cells, overview Mus musculus ?
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 ?

Synonyms

Synonyms Comment Organism
calcium-dependent tyrosine kinase PYK2
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 Mus musculus
Pyk2
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 Mus musculus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Mus musculus