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Literature summary for 2.7.10.2 extracted from

  • Hu, X.; Dang, Y.; Tenney, K.; Crews, P.; Tsai, C.W.; Sixt, K.M.; Cole, P.A.; Liu, J.O.
    Regulation of c-Src nonreceptor tyrosine kinase activity by bengamide A through inhibition of methionine aminopeptidases (2007), Chem. Biol., 14, 764-774.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.10.2

Inhibitors

Inhibitors Comment Organism Structure
bengamide A c-Src from bengamide A-treated cells retains its N-terminal methionine and suffers a decrease in N-terminal myristoylation, which is accompanied by a shift of its subcellular distribution from the plasma membrane to the cytosol, and decreased tyrosine kinase activities of c-Src both in vitro and in vivo and eventually delayed cell-cycle progression through G2/M, overview, bengamide A reduced tyrosine phosphorylation on a few proteins, and is not a general tyrosine kinase inhibitor Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
additional information c-Src from bengamide A-treated cells retains its N-terminal methionine and suffers a decrease in N-terminal myristoylation, which is accompanied by a shift of its subcellular distribution from the plasma membrane to the cytosol, overview Homo sapiens
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens c-Src is a physiologically relevant substrate for Methionine aminopeptidases, whose dysfunction is likely to account for the cell-cycle effects of MetAP inhibitors including bengamide A, overview ?
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
HCT-116 cell
-
 Homo sapiens
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HeLa cell
-
 Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information c-Src is a physiologically relevant substrate for Methionine aminopeptidases, whose dysfunction is likely to account for the cell-cycle effects of MetAP inhibitors including bengamide A, overview Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
c-Src nonreceptor tyrosine kinase
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 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens