Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Epidermal growth factor | activates fyn | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expression of GST-tagged active full-length fyn and GST-tagged fyn fragments in HEK-293 cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | inhibition of epidermal growth factor stimulation inhibits fyn enzyme activity | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + PIKE-A | Homo sapiens | i.e. phosphatidylinositol 3-kinase enhancer-activating Akt, phosphorylation by fyn is essential for PIKE-A complex formation and apoptotic cleavage, overview | ADP + phosphotyrosinyl-PIKE-A | - |
? | |
additional information | Homo sapiens | the Src-family tyrosine kinase fyn phosphorylates phosphatidylinositol 3-kinase enhancer-activating Akt, preventing its apoptotic cleavage and promoting cell survival, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | fyn is activated by phosphorylation | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + PIKE-A | i.e. phosphatidylinositol 3-kinase enhancer-activating Akt, phosphorylation by fyn is essential for PIKE-A complex formation and apoptotic cleavage, overview | Homo sapiens | ADP + phosphotyrosinyl-PIKE-A | - |
? | |
ATP + PIKE-A | i.e. phosphatidylinositol 3-kinase enhancer-activating Akt, phosphorylation at Y682 and Y774 by fyn, the kinase domain of activated fyn binds to the ArfGAP domain of PIKE-A, reduced activity with Y682F and with Y774F mutant PIKE-A, no activity with Y682F/Y774F mutant PIKE-A | Homo sapiens | ADP + phosphotyrosinyl-PIKE-A | - |
? | |
additional information | the Src-family tyrosine kinase fyn phosphorylates phosphatidylinositol 3-kinase enhancer-activating Akt, preventing its apoptotic cleavage and promoting cell survival, overview | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Fyn | - |
Homo sapiens |
More | the enzyme belongs to the Src tyrosine kinase family | Homo sapiens |