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Literature summary for 2.7.10.2 extracted from

  • Tang, X.; Feng, Y.; Ye, K.
    Src-family tyrosine kinase fyn phosphorylates phosphatidylinositol 3-kinase enhancer-activating Akt, preventing its apoptotic cleavage and promoting cell survival (2007), Cell Death Differ., 14, 368-377.
    View publication on PubMed
Search for more literature for 2.7.10.2

Activating Compound

Activating Compound Comment Organism Structure
Epidermal growth factor activates fyn Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expression of GST-tagged active full-length fyn and GST-tagged fyn fragments in HEK-293 cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information inhibition of epidermal growth factor stimulation inhibits fyn enzyme activity Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + PIKE-A Homo sapiens i.e. phosphatidylinositol 3-kinase enhancer-activating Akt, phosphorylation by fyn is essential for PIKE-A complex formation and apoptotic cleavage, overview ADP + phosphotyrosinyl-PIKE-A
-
 ?
additional information Homo sapiens the Src-family tyrosine kinase fyn phosphorylates phosphatidylinositol 3-kinase enhancer-activating Akt, preventing its apoptotic cleavage and promoting cell survival, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein fyn is activated by phosphorylation Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + PIKE-A i.e. phosphatidylinositol 3-kinase enhancer-activating Akt, phosphorylation by fyn is essential for PIKE-A complex formation and apoptotic cleavage, overview Homo sapiens ADP + phosphotyrosinyl-PIKE-A
-
 ?
ATP + PIKE-A i.e. phosphatidylinositol 3-kinase enhancer-activating Akt, phosphorylation at Y682 and Y774 by fyn, the kinase domain of activated fyn binds to the ArfGAP domain of PIKE-A, reduced activity with Y682F and with Y774F mutant PIKE-A, no activity with Y682F/Y774F mutant PIKE-A Homo sapiens ADP + phosphotyrosinyl-PIKE-A
-
 ?
additional information the Src-family tyrosine kinase fyn phosphorylates phosphatidylinositol 3-kinase enhancer-activating Akt, preventing its apoptotic cleavage and promoting cell survival, overview Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
Fyn
-
 Homo sapiens
More the enzyme belongs to the Src tyrosine kinase family Homo sapiens