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Literature summary for 2.7.10.2 extracted from

  • Wallace, T.A.; Sayeski, P.P.
    Jak2 tyrosine kinase: a mediator of both housekeeping and ligand-dependent gene expression? (2006), Cell Biochem. Biophys., 44, 213-222.
    View publication on PubMed
Search for more literature for 2.7.10.2

Activating Compound

Activating Compound Comment Organism Structure
cytokine receptors
-
 Drosophila melanogaster
cytokine receptors
-
 Mus musculus
cytokine receptors
-
 Homo sapiens
additional information different activation mechanisms for Jak2 Drosophila melanogaster
additional information different activation mechanisms for Jak2 Mus musculus
additional information different activation mechanisms for Jak2 Homo sapiens
tyrosine growth factor the enzyme is activated by the tyrosine growth factor and seven transmembrane-spanning receptors Drosophila melanogaster
tyrosine growth factor the enzyme is activated by the tyrosine growth factor and seven transmembrane-spanning receptors Mus musculus
tyrosine growth factor the enzyme is activated by the tyrosine growth factor and seven transmembrane-spanning receptors Homo sapiens

Protein Variants

Protein Variants Comment Organism
E695K mutation in the JH2 domain of the Jak homologue hopscotch, which renders the kinase hyperactive and causes hematopoietic hyperplasia Drosophila melanogaster
additional information construction of a transcription factor TEL-Jak2 fusion chimeric protein, leading to increase in nuclear factor IkappaB and growthfactor-independent cell proliferation, overview Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Drosophila melanogaster 5829
-
cytosol
-
 Mus musculus 5829
-
cytosol
-
 Homo sapiens 5829
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
130000
-
 approximately Drosophila melanogaster
130000
-
 approximately Mus musculus
130000
-
 approximately Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Drosophila melanogaster Jak2 is involved in transcriptional signaling and ligand-independent gene expression, and increases the activity of erythropoietin receptor cell-surface expression, overview, enzyme deficiency is involved in lymphoid leukemia, overview ?
-
 ?
additional information Mus musculus Jak2 is involved in transcriptional signaling and ligand-independent gene expression, and increases the activity of erythropoietin receptor cell-surface expression, overview, enzyme deficiency is involved in lymphoid leukemia, overview ?
-
 ?
additional information Homo sapiens Jak2 is involved in transcriptional signaling and ligand-independent gene expression, and increases the activity of erythropoietin receptor cell-surface expression, overview, enzyme deficiency is involved in lymphoid leukemia, overview ?
-
 ?
STAT transcription activator protein + ATP Drosophila melanogaster activation of STAT by phosphorylation is required for translocation to the nucleus, the enzyme regulates the cytokine expression via STAT, overview phosphorylated STAT transcription activator protein + ADP
-
 ?
STAT transcription activator protein + ATP Mus musculus activation of STAT by phosphorylation is required for translocation to the nucleus, the enzyme regulates the cytokine expression via STAT, overview phosphorylated STAT transcription activator protein + ADP
-
 ?
STAT transcription activator protein + ATP Homo sapiens activation of STAT by phosphorylation is required for translocation to the nucleus, the enzyme regulates the cytokine expression via STAT, overview phosphorylated STAT transcription activator protein + ADP
-
 ?

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster
-
-
-
Homo sapiens
-
-
-
Mus musculus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein phosphorylation of the activation loop is required for Jak2 activity, the enzyme shows multiple activation stages, phosphorylation by e.g. the Jak2-modifying protein SH2B-b, and by autophosphorylation Drosophila melanogaster
phosphoprotein phosphorylation of the activation loop is required for Jak2 activity, the enzyme shows multiple activation stages, phosphorylation by e.g. the Jak2-modifying protein SH2B-b, and by autophosphorylation Homo sapiens
phosphoprotein phosphorylation of the activation loop, especially at Tyr1007, is essential for Jak2 activity, the enzyme shows multiple activation stages, phosphorylation by e.g. the Jak2-modifying protein SH2B-b, and by autophosphorylation Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
lymphocyte
-
 Mus musculus
-
additional information the enzyme shows a wide tissue distribution Drosophila melanogaster
-
additional information the enzyme shows a wide tissue distribution Mus musculus
-
additional information the enzyme shows a wide tissue distribution Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information Jak2 is involved in transcriptional signaling and ligand-independent gene expression, and increases the activity of erythropoietin receptor cell-surface expression, overview, enzyme deficiency is involved in lymphoid leukemia, overview Drosophila melanogaster ?
-
 ?
additional information Jak2 is involved in transcriptional signaling and ligand-independent gene expression, and increases the activity of erythropoietin receptor cell-surface expression, overview, enzyme deficiency is involved in lymphoid leukemia, overview Mus musculus ?
-
 ?
additional information Jak2 is involved in transcriptional signaling and ligand-independent gene expression, and increases the activity of erythropoietin receptor cell-surface expression, overview, enzyme deficiency is involved in lymphoid leukemia, overview Homo sapiens ?
-
 ?
additional information receptor-bound Jak2 allows the transphosphorylation of the dimeric receptor molecule one another Drosophila melanogaster ?
-
 ?
additional information receptor-bound Jak2 allows the transphosphorylation of the dimeric receptor molecule one another Mus musculus ?
-
 ?
additional information receptor-bound Jak2 allows the transphosphorylation of the dimeric receptor molecule one another Homo sapiens ?
-
 ?
STAT transcription activator protein + ATP activation of STAT by phosphorylation is required for translocation to the nucleus, the enzyme regulates the cytokine expression via STAT, overview Drosophila melanogaster phosphorylated STAT transcription activator protein + ADP
-
 ?
STAT transcription activator protein + ATP activation of STAT by phosphorylation is required for translocation to the nucleus, the enzyme regulates the cytokine expression via STAT, overview Mus musculus phosphorylated STAT transcription activator protein + ADP
-
 ?
STAT transcription activator protein + ATP activation of STAT by phosphorylation is required for translocation to the nucleus, the enzyme regulates the cytokine expression via STAT, overview Homo sapiens phosphorylated STAT transcription activator protein + ADP
-
 ?
STAT transcription activator protein + ATP phosphorylation by Jak2 at tyrosine residues Drosophila melanogaster phosphorylated STAT transcription activator protein + ADP
-
 ?
STAT transcription activator protein + ATP phosphorylation by Jak2 at tyrosine residues Mus musculus phosphorylated STAT transcription activator protein + ADP
-
 ?
STAT transcription activator protein + ATP phosphorylation by Jak2 at tyrosine residues Homo sapiens phosphorylated STAT transcription activator protein + ADP
-
 ?

Subunits

Subunits Comment Organism
More domain structure including catalytic and ligand binding domains, and an activation loop spanning from Asp994 to Glu1024, the domains are termed JH1 to JH7, overview Mus musculus
More domain structure including catalytic and ligand binding domains, and an activation loop, the domains are termed JH1 to JH7, overview Drosophila melanogaster
More domain structure including catalytic and ligand binding domains, and an activation loop, the domains are termed JH1 to JH7, overview Homo sapiens

Synonyms

Synonyms Comment Organism
JAK2
-
 Drosophila melanogaster
JAK2
-
 Mus musculus
JAK2
-
 Homo sapiens
More the enzyme belongs to the Janus family of tyrosine kinases Drosophila melanogaster
More the enzyme belongs to the Janus family of tyrosine kinases Mus musculus
More the enzyme belongs to the Janus family of tyrosine kinases Homo sapiens
nonreceptor tyrosine kinase
-
 Drosophila melanogaster
nonreceptor tyrosine kinase
-
 Mus musculus
nonreceptor tyrosine kinase
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Drosophila melanogaster
ATP
-
 Mus musculus
ATP
-
 Homo sapiens