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Literature summary for 2.7.10.2 extracted from

  • Merciris, P.; Claussen, W.J.; Joiner, C.H.; Giraud, F.
    Regulation of K-Cl cotransport by Syk and Src protein tyrosine kinases in deoxygenated sickle cells (2003), Pflugers Arch., 446, 232-238.
    View publication on PubMed
Search for more literature for 2.7.10.2

Activating Compound

Activating Compound Comment Organism Structure
additional information deoxygenation of SS cells increases Syk and Lyn PTK activities, overview Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
4-amino-5-(4-chlorophenyl)-7-(tert-butyl)pyrazolo[3,4-d]pyrimidine i.e. pp2, inhibits Src family members like Lyn, no inhibition of Syk Homo sapiens
4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo[3,4-d]pyrimidine i.e. pp1, inhibits Src family members like Lyn, no inhibition of Syk Homo sapiens
methyl 2,5-dihydroxycinnamate i.e. DHC, inhibition of Syk and Lyn Homo sapiens
additional information effects of inhibitors in vivo in SS cells on K-Cl cotransport, overview Homo sapiens
staurosporine i.e. ST, inhibition of Syk and Lyn, IC50 for Syk is 0.008 mM Homo sapiens
T47 57% inhibition of Syk at 0.1 mM Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Homo sapiens 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + a [protein]-L-tyrosine Homo sapiens activation of Syk is responsible for K-Cl cotransport in SS cells by relieving Src-mediated inhibition of the transporter ADP + a [protein]-L-tyrosine phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood
-
 Homo sapiens
-
erythrocyte
-
 Homo sapiens
-
sickle cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + a [protein]-L-tyrosine
-
 Homo sapiens ADP + a [protein]-L-tyrosine phosphate
-
 ?
ATP + a [protein]-L-tyrosine activation of Syk is responsible for K-Cl cotransport in SS cells by relieving Src-mediated inhibition of the transporter Homo sapiens ADP + a [protein]-L-tyrosine phosphate
-
 ?

Synonyms

Synonyms Comment Organism
Lyn
-
 Homo sapiens
More Syk belongs to the Syk family of protein tyrosine kinases, Src and Lyn belong to the Src family of protein tyrosine kinases Homo sapiens
non-receptor PTK
-
 Homo sapiens
Protein tyrosine kinase
-
 Homo sapiens
PTK
-
 Homo sapiens
Src
-
 Homo sapiens
Syk
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.008
-
 i.e. ST, inhibition of Syk and Lyn, IC50 for Syk is 0.008 mM Homo sapiens staurosporine