Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | the leukemia inhibitory factor LIF and other growth factors are linked to Src family kinase activation | Mus musculus |
Cloned (Comment) | Organism |
---|---|
expression of SFKs Hck, Fyn, Lck, and Yes in human 293T cells, expression of N-terminally His-tagged Hck in Spodoptera frugiperda Sf9 cells via baculovirus infection system | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4-amino-5-(4-chlorophenyl)-7-(tert-butyl)pyrazolo[3,4-d] pyrimidine | i.e. pp2, broad spectrum SFK inhibitor, competitive to ATP, in vitro and in vivo | Mus musculus | |
A-419259 | high inhibition of SFKs | Mus musculus | |
Src kinase inhibitor-1 | i.e. SKI-1, a 4-anilinoquinazoline, moderate inhibition in vitro and vivo | Mus musculus | |
SU6656 | more specific for Yes kinase than for other SFKs | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Mus musculus | 5737 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mus musculus | Src family kinases Hck, Fyn and Src are constitutively expressed and are required for murine embryonic stem cell growth and differentiation, regulation of SFKs in response to leukemia inhibitory factor LIF and other growth factors, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
embryo | - |
Mus musculus | - |
embryonic stem cell | - |
Mus musculus | - |
ES-D3 cell | ES cell D3 line, embryonic stem cell, expression of 7 different Src family kinases, 3 are involved in differentiation to embryoid bodies | Mus musculus | - |
additional information | SFK expression profiling in developing embryoid bodies | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Src family kinases Hck, Fyn and Src are constitutively expressed and are required for murine embryonic stem cell growth and differentiation, regulation of SFKs in response to leukemia inhibitory factor LIF and other growth factors, overview | Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Fgr | - |
Mus musculus |
Fyn | - |
Mus musculus |
HCK | - |
Mus musculus |
Lck | - |
Mus musculus |
Lyn | - |
Mus musculus |
More | enzymes belonging to the Src kinase family | Mus musculus |
SFK | - |
Mus musculus |
Src | - |
Mus musculus |
Src family kinase | - |
Mus musculus |
Yes | - |
Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Mus musculus |