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Literature summary for 2.7.10.2 extracted from

  • Meyn, M.A., 3rd; Schreiner, S.J.; Dumitrescu, T.P.; Nau, G.J.; Smithgall, T.E.
    Src family kinase activity is required for murine embryonic stem cell growth and differentiation (2005), Mol. Pharmacol., 68, 1320-1330.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information the leukemia inhibitory factor LIF and other growth factors are linked to Src family kinase activation Mus musculus

Cloned(Commentary)

Cloned (Comment) Organism
expression of SFKs Hck, Fyn, Lck, and Yes in human 293T cells, expression of N-terminally His-tagged Hck in Spodoptera frugiperda Sf9 cells via baculovirus infection system Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
4-amino-5-(4-chlorophenyl)-7-(tert-butyl)pyrazolo[3,4-d] pyrimidine i.e. pp2, broad spectrum SFK inhibitor, competitive to ATP, in vitro and in vivo Mus musculus
A-419259 high inhibition of SFKs Mus musculus
Src kinase inhibitor-1 i.e. SKI-1, a 4-anilinoquinazoline, moderate inhibition in vitro and vivo Mus musculus
SU6656 more specific for Yes kinase than for other SFKs Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
Mus musculus 5737
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus Src family kinases Hck, Fyn and Src are constitutively expressed and are required for murine embryonic stem cell growth and differentiation, regulation of SFKs in response to leukemia inhibitory factor LIF and other growth factors, overview ?
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
embryo
-
Mus musculus
-
embryonic stem cell
-
Mus musculus
-
ES-D3 cell ES cell D3 line, embryonic stem cell, expression of 7 different Src family kinases, 3 are involved in differentiation to embryoid bodies Mus musculus
-
additional information SFK expression profiling in developing embryoid bodies Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information Src family kinases Hck, Fyn and Src are constitutively expressed and are required for murine embryonic stem cell growth and differentiation, regulation of SFKs in response to leukemia inhibitory factor LIF and other growth factors, overview Mus musculus ?
-
?

Synonyms

Synonyms Comment Organism
Fgr
-
Mus musculus
Fyn
-
Mus musculus
HCK
-
Mus musculus
Lck
-
Mus musculus
Lyn
-
Mus musculus
More enzymes belonging to the Src kinase family Mus musculus
SFK
-
Mus musculus
Src
-
Mus musculus
Src family kinase
-
Mus musculus
Yes
-
Mus musculus

Cofactor

Cofactor Comment Organism Structure
ATP
-
Mus musculus