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Literature summary for 2.7.10.2 extracted from

  • Puder, C.; Wagner, K.; Vettermann, R.; Hauptmann, R.; Potterat, O.
    Terphenylquinone inhibitors of the Src protein tyrosine kinase from Stilbella sp (2005), J. Nat. Prod., 68, 323-326.
    View publication on PubMed
Search for more literature for 2.7.10.2

Cloned(Commentary)

Cloned (Comment) Organism
expression of His-tagged Src kinase in Spodoptera frugiperda Sf9 cells via baculovirus infection system Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
2,5-dihydroxy-3-(3,4-dihydroxyphenyl)-6-phenyl-1,4-benzoquinone secondary metabolite isolated from fungus Stilbella sp. strain 1586 Homo sapiens
2,5-dihydroxy-3-phenyl-6-(3,4,5-trihydroxyphenyl)-1,4-benzoquinone secondary metabolite isolated from fungus Stilbella sp. strain 1586 Homo sapiens
2,7,8-trihydroxy-3-phenyl-1,4-dibenzofurandione secondary metabolite isolated from fungus Stilbella sp. strain 1586 Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant His-tagged Src kinase from Sf9 insect cells by nickel affinity chromatography Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + poly(Glu4-Tyr)
-
 Homo sapiens ADP + poly(Glu4-Tyr)-L-tyrosine phosphate
-
 ?

Synonyms

Synonyms Comment Organism
Src kinase
-
 Homo sapiens
Src protein tyrosine kinase
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
22
-
 assay at room temperature Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens