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Literature summary for 2.7.10.2 extracted from
- Curcumin suppresses Janus kinase-STAT inflammatory signaling through activation of Src homology 2 domain-containing tyrosine phosphatase 2 in brain microglia (2003), J. Immunol., 171, 6072-6079.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| curcumin | inhibits the JAK-STAT signaling cascade via activation of SHP-2, a SH2 domain-containing phosphatase, and increase in JAK-SHP-2 interaction contributing to anti-inflammatory activity in the brain, suppresses STAT-responsive inflammatory gene expression | Homo sapiens |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | the Janus kinase is involved in the JAK-STAT signaling cascade causing inflammatory activity in the brain | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
JAK1 and JAK2 | - |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| phosphoprotein | phosphorylation of JAK1 and JAK2, can be inhibited by curcumin | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | the Janus kinase is involved in the JAK-STAT signaling cascade causing inflammatory activity in the brain | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| JAK | - |
Homo sapiens |
| Janus kinase | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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